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Titolo:
Effects of early adverse experiences on brain structure and function: Clinical implications
Autore:
Kaufman, J; Plotsky, PM; Nemeroff, CB; Charney, DS;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 , Dept Psychiat, New Haven, CT 06511 USA Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA Emory Univ Atlanta GA USA ed, Dept Psychiat & Behav Sci, Atlanta, GA USA NIMH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Bethesda, MD 20892 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 48, anno: 2000,
pagine: 778 - 790
SICI:
0006-3223(20001015)48:8<778:EOEAEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; POSTTRAUMATIC-STRESS-DISORDER; PREFRONTAL CORTICAL PROJECTIONS; PITUITARY-ADRENOCORTICAL AXIS; RECURRENT MAJOR DEPRESSION; CA3 PYRAMIDAL NEURONS; HIPPOCAMPAL VOLUME; PARAVENTRICULAR NUCLEUS; CEREBROSPINAL-FLUID; MATERNAL SEPARATION;
Keywords:
depression; corticotropin-releasing hormone (CRH); child abuse; animal models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufman, J Yale Univ, Sch Med, Dept Psychiat, Univ Towers,Suite 2H,100 York St, New Haven, CT 06511 USA Yale Univ Univ Towers,Suite 2H,100 York St New Haven CT USA 06511
Citazione:
J. Kaufman et al., "Effects of early adverse experiences on brain structure and function: Clinical implications", BIOL PSYCHI, 48(8), 2000, pp. 778-790

Abstract

Child abuse is associated with markedly elevated rates of major depressionand other psychiatric disorders in adulthood. This article reviews preclinical studies examining the effects of early stress, factors that modify theimpact of these experiences, and neurobiological changes associated with major depression. Preclinical studies demonstrate that early stress can alter the development of the hypothalamic-pituitary-adrenal axis, hypothalamic and extrahypothalamic corticotropin releasing hormone, monoaminergic, and gamma -aminobutyric acid/benzodiazepine systems, Stress has also been shown to promote structural and functional alterations in brain regions similar to those seen in adults with depression. Emerging data suggest, however, that the long-term effects of early sa-ess can be moderated by genetic factorsand the quality of the subsequent caregiving environment, These effects also can be prevented or reversed with various pharmacologic interventions. Preclinical studies of early stress can provide valuable insights in understanding the pathophysiology and treatment of major depression. They also canprovide an important tool to use to investigate interactions between genesand environments in determining an individual's sensitivity to stress, More research is needed to understand how inherent factors interact with experiences of abuse and other psychosocial factors to confer vulnerability to develop depression, Biol Psychiatry 2000;48: 778-790 (C) 2000 Society of Biological Psychiatry.

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Documento generato il 17/01/20 alle ore 20:18:45