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Titolo:
Role of the macrophage galactose lectin in the uptake of desialylated LDL
Autore:
Bartlett, AL; Grewal, T; De Angelis, E; Myers, S; Stanley, KK;
Indirizzi:
Univ New S Wales, Ctr Immunol, Sydney, NSW 2010, Australia Univ New S Wales Sydney NSW Australia 2010 l, Sydney, NSW 2010, Australia St Vincents Hosp, Sydney, NSW 2010, Australia St Vincents Hosp Sydney NSWAustralia 2010 p, Sydney, NSW 2010, Australia Univ Hamburg, Hosp Eppendorf, Med Clin 1, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 ed Clin 1, D-20246 Hamburg, Germany Univ Cambridge, Dept Med, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY Med, Cambridge CB2 2XY, England Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 2XY, England Addenbrookes Hosp Cambridge England CB2 2XY , Cambridge CB2 2XY, England Heart Res Inst, Camperdown, NSW 2050, Australia Heart Res Inst CamperdownNSW Australia 2050 perdown, NSW 2050, Australia
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 153, anno: 2000,
pagine: 219 - 230
SICI:
0021-9150(200011)153:1<219:ROTMGL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SIALIC-ACID CONTENT; INTRACELLULAR LIPID-ACCUMULATION; HUMAN MONOCYTE-MACROPHAGES; CORONARY-ARTERY DISEASE; N-ACETYLGALACTOSAMINE; SCAVENGER-RECEPTOR; MOLECULAR-CLONING; IN-VIVO; EXPRESSION;
Keywords:
desialylated LDL; lectin; lipopolysaccharide; MMGL; scavenger receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Stanley, KK Univ New S Wales, Ctr Immunol, Sydney, NSW 2010, Australia Univ New S Wales Sydney NSW Australia 2010 SW 2010, Australia
Citazione:
A.L. Bartlett et al., "Role of the macrophage galactose lectin in the uptake of desialylated LDL", ATHEROSCLER, 153(1), 2000, pp. 219-230

Abstract

Desialylated low density lipoprotein (LDL) is rapidly taken up and accumulated by both peripheral blood monocytes and cells isolated from human arterial intima consisting predominantly of smooth muscle cells. It is shown that thioglycollate (TG)-elicited mouse macrophages and mouse peritoneal macrophages stimulated with lipopolysaccharide (LPS) show increased expression of a membrane-bound, galactose-specific lectin that could be responsible forthis uptake. In LPS-stimulated macrophages accumulation of desialylated LDL is increased ca. 2.6-fold. Accumulation of acetylated LDL in the same cells is reduced, suggesting that the galactose-specific lectin might be responsible for the uptake of desialylated LDL. Transfection of cells with the mouse macrophage Gal/GalNAc-specific lectin (MMGL) increased their capacity to take up asialofetuin (ASF) and, to a smaller extent, desialylated LDL. The uptake of desialylated LDL was small, most likely due to the high k(d) of MMGL for biantennary oligosaccharides as found on LDL, and low concentration of LDL achieved in tissue culture experiments. The data suggest that the expression of galactose-specific lectins can be elevated under inflammatory conditions, and that these receptors could contribute to foam cell formation under conditions of high desialylated LDL concentration, as might be found in arterial intima. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:56:21