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Titolo:
Mapping auditory hallucinations in schizophrenia using functional magneticresonance imaging
Autore:
Shergill, SS; Brammer, MJ; Williams, SCR; Murray, RM; McGuire, PK;
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 11, volume: 57, anno: 2000,
pagine: 1033 - 1038
SICI:
0003-990X(200011)57:11<1033:MAHISU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGHT-HEMISPHERE; SIGNAL CHANGE; INNER SPEECH; HUMAN BRAIN; BLOOD-FLOW; ACTIVATION; FMRI; NEUROANATOMY; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Shergill et al., "Mapping auditory hallucinations in schizophrenia using functional magneticresonance imaging", ARCH G PSYC, 57(11), 2000, pp. 1033-1038

Abstract

Background: Perceptions of speech in the absence of an auditory stimulus (auditory verbal hallucinations) are a cardinal feature of schizophrenia. Functional neuroimaging provides a powerful. means of measuring neural activity during auditory hallucinations, but the results from previous studies have been inconsistent. This may reflect the acquisition of small numbers of images in each subject and the confounding effects of patients actively signaling when hallucinations occur. Methods: We examined 6 patients with schizophrenia who were experiencing frequent auditory hallucinations, using a novel functional magnetic resonance imaging method that permitted the measurement of spontaneous neural activity without requiring subjects to signal when hallucinations occurred. Approximately 50 individual scans were acquired at unpredictable intervals in each subject while they were intermittently hallucinating. Immediately aftereach scan, subjects reported whether they had been hallucinating at that instant. Neural activity when patients were and were not experiencing hallucinations was compared in each subject and the group as a whole. Results: Auditory hallucinations were associated with activation in the inferior frontal/insular, anterior cingulate, and temporal cortex bilaterally(with greater responses on the right), the right thalamus and inferior colliculus, and the left hippocampus and parahippocampal cortex (P<.0001). Conclusions: Auditory hallucinations may be mediated by a distributed network of cortical and subcortical areas. Previous neuroimaging studies of auditory hallucinations may have identified different components of this network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:03:23