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Titolo:
Autosomal, mtDNA, and Y-chromosome diversity in Amerinds: Pre- and post-Columbian patterns of gene flow in South America
Autore:
Mesa, NR; Mondragon, MC; Soto, ID; Parra, MV; Duque, C; Ortiz-Barrientos, D; Garcia, LF; Velez, ID; Bravo, ML; Munera, JG; Bedoya, G; Bortolini, MC; Ruiz-Linares, A;
Indirizzi:
Univ Antioquia, Fac Med, Dept Bioquim & Fisiol, Genet Mol Lab, Medellin, Colombia Univ Antioquia Medellin Colombia iol, Genet Mol Lab, Medellin, Colombia Univ Antioquia, Fac Med, Lab Cent Invest, Medellin, Colombia Univ Antioquia Medellin Colombia d, Lab Cent Invest, Medellin, Colombia Univ Antioquia, Fac Med, PECET, Medellin, Colombia Univ Antioquia Medellin Colombia ia, Fac Med, PECET, Medellin, Colombia Univ Antioquia, Dept Biol, Medellin, Colombia Univ Antioquia Medellin Colombia tioquia, Dept Biol, Medellin, Colombia Univ Antioquia, Dept Antropol, Medellin, Colombia Univ Antioquia Medellin Colombia uia, Dept Antropol, Medellin, Colombia Univ Fed Rio Grande Sul, Dept Genet, Porto Alegre, RS, Brazil Univ Fed RioGrande Sul Porto Alegre RS Brazil Porto Alegre, RS, Brazil Northwick Pk Hosp, Imperial Coll, Sch Med, Dept Med & Community Genet, Harrow HA1 3UJ, Middx, England Northwick Pk Hosp Harrow Middx England HA1 3UJow HA1 3UJ, Middx, England
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 67, anno: 2000,
pagine: 1277 - 1286
SICI:
0002-9297(200011)67:5<1277:AMAYDI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II ALLELES; CLUSTER HAPLOTYPES; HUMAN-EVOLUTION; NEW-WORLD; POPULATION-GENETICS; MOLECULAR ANALYSIS; HIGH-RESOLUTION; TANDEM REPEATS; MITOCHONDRIAL; TRIBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Ruiz-Linares, A Univ London Univ Coll, Dept Biol, Wolfson House,4 Stephenson Way, London NW1 2HE, England Univ London Univ Coll Wolfson House,4 Stephenson Way London England NW1 2HE
Citazione:
N.R. Mesa et al., "Autosomal, mtDNA, and Y-chromosome diversity in Amerinds: Pre- and post-Columbian patterns of gene flow in South America", AM J HU GEN, 67(5), 2000, pp. 1277-1286

Abstract

To evaluate sex-specific differences in gene flow between Native American populations from South America and between those populations and recent immigrants to the New World, we examined the genetic diversity at uni- and biparental genetic markers of five Native American populations from Colombia and in published surveys from native South Americans. The Colombian populations were typed for five polymorphisms in mtDNA, five restriction sites in the beta -globin gene cluster, the DQA1 gene, and nine autosomal microsatellites. Elsewhere, we published results for seven Y-chromosome microsatellites in the same populations. Autosomal polymorphisms showed a mean G(ST) of 6.8%, in agreement with extensive classical marker studies of South Americanpopulations. MtDNA and Y-chromosome markers resulted in G(ST) values of 0.18 and 0.165, respectively. When only Y chromosomes of confirmed Amerind origin were used in the calculations las defined by the presence of allele T at locus DYS199), G(ST) increased to 0.22. G(ST) values calculated from published data for other South American natives were 0.3 and 0.29 for mtDNA and Amerind Y chromosomes, respectively. The concordance of these estimates does not support an important difference in migration rates between the sexes throughout the history of South Amerinds. Admixture analysis of the Colombian populations suggests an asymmetric pattern of mating involving mostly immigrant men and native women.

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Documento generato il 27/11/20 alle ore 15:14:24