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Titolo:
Molecular mechanisms of mutations induced by DNA lesions
Autore:
Kamiya, H;
Indirizzi:
Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan
Titolo Testata:
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
fascicolo: 11, volume: 120, anno: 2000,
pagine: 1159 - 1171
SICI:
0031-6903(200011)120:11<1159:MMOMIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
JPN
Soggetto:
C-HA-RAS; ESCHERICHIA-COLI; MAMMALIAN-CELLS; BASE DAMAGE; 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE; SEQUENCE CONTEXTS; LAGGING-STRAND; OPPOSITE 2-HYDROXYADENINE; ADJACENT POSITIONS; IONIZING-RADIATION;
Keywords:
DNA lesion; reactive oxygen species; 2-hydroxyadenine; 8-hydroxyguanine; mutation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Kamiya, H Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Kita 12,Nishi 6, Sapporo,Hokkaido 0600812, Japan Hokkaido Univ Kita 12,Nishi 6 Sapporo Hokkaido Japan 0600812 pan
Citazione:
H. Kamiya, "Molecular mechanisms of mutations induced by DNA lesions", YAKUGAKU ZA, 120(11), 2000, pp. 1159-1171

Abstract

Oligodeoxyribonucleotides containing a DNA lesion were synthesized and inserted into vector DNAs to introduce the lesion at a predetermined site. Themanipulated DNAs were transfected into living mammalian cells and the mutants induced by the DNA lesion were collected and analyzed. This approach was applied to various DNA lesions produced in cells by reactive oxygen species, chemicals, and ultraviolet light. In addition, the mutations induced bydamaged DNA precursors were studied by the use of chemically synthesized nucleoside triphosphates. In this review article, the author summarizes the results obtained by these types of experiments, focusing on two oxidativelydamaged compounds, 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) and 2-hydroxyadenine (1,2-dihydro-2-oxoadenine).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:33:15