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Titolo:
Synergistic interaction between CCK and leptin to regulate food intake
Autore:
Wang, LX; Barachina, MD; Martinez, V; Wei, JY; Tache, Y;
Indirizzi:
Univ Calif Los Angeles, Digest Dis Res Ctr, CURE, Los Angeles, CA 90073 USA Univ Calif Los Angeles Los Angeles CA USA 90073 Los Angeles, CA 90073 USA VA Greater Los Angeles Healthcare Syst, Dept Med, Div Digest Dis, Los Angeles, CA 90073 USA VA Greater Los Angeles Healthcare Syst Los Angeles CA USA 90073 90073 USA VA Greater Los Angeles Healthcare Syst, Brain Res Inst, Los Angeles, CA 90073 USA VA Greater Los Angeles Healthcare Syst Los Angeles CA USA 90073 90073 USA Univ Valencia, Sch Med, Dept Pharmacol, Valencia, Spain Univ Valencia Valencia Spain , Sch Med, Dept Pharmacol, Valencia, Spain CEU San Pablo, Sch Vet, Dept Physiol, Valencia 46113, Spain CEU San PabloValencia Spain 46113 , Dept Physiol, Valencia 46113, Spain
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-3, volume: 92, anno: 2000,
pagine: 79 - 85
SICI:
0167-0115(20000825)92:1-3<79:SIBCAL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; C-FOS EXPRESSION; BODY-WEIGHT REGULATION; CENTRAL-NERVOUS-SYSTEM; OBESE GENE; PARAVENTRICULAR NUCLEUS; PANCREATIC GLUCAGON; ENERGY-BALANCE; OB PROTEIN; BRAIN-STEM;
Keywords:
cholecystokinin; feeding behavior; vagus; satiety; body weight; gastric emptying; nucleus tractus solitarius; paraventricular nucleus of the hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, LX Univ Calif Los Angeles, Digest Dis Res Ctr, CURE, Bldg 115,Room 203,11301 Wilshire Blvd, Los Angeles, CA 90073 USA Univ Calif Los Angeles Bldg 115,Room 203,11301 Wilshire Blvd Los Angeles CA USA 90073
Citazione:
L.X. Wang et al., "Synergistic interaction between CCK and leptin to regulate food intake", REGUL PEPT, 92(1-3), 2000, pp. 79-85

Abstract

Leptin administered (either intracerebroventricularly, icv, or intraperitoneally, ip) acts in synergy with CCK to suppress food intake and body weight in lean mice or rats. The potentiating effect induced by the co-injectionof ip CCK and leptin to inhibit food consumption in mice is mediated by the CCK-A receptor and capsaicin sensitive afferents. In vitro, studies: in rats showed that a subset of gastric vagal afferent fibers responded to leptin injected directly into the gastric artery only after a prior intra-arterial CCK injection. Moreover, the tonic activity of gastric-related neurons in the nucleus tractus solitarius (NTS) increased when leptin was deliveredinto the gastric chamber of an in vitro stomach-brainstem preparation. CCKco-injected with leptin potentiated Fos expression selectively in the areapostrema, NTS and paraventricular nucleus of the hypothalamus (PVN), whichpoints to the PVN as part of the afferent and efferent limbs of the circuitry involved in the synergistic interaction between leptin and CCK. The dampening of CCK or leptin inhibitory action on ingestive behavior when eitherfactor is not present or their receptors are non functional supports the notion that such leptin-CCK interaction may have a physiological relevance. These observations provide a mean through which leptin and CCK integrate short- and mid-term meal-related input signals into long-term control of energy balance. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 23:23:00