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Titolo:
Monitoring of tumor microcirculation during fractionated radiation therapyin patients with rectal carcinoma: Preliminary results and implications for therapy
Autore:
de Vries, A; Griebel, J; Kremser, C; Judmaier, W; Gneiting, T; Debbage, P; Kremser, T; Pfeiffer, KP; Buchberger, W; Lukas, P;
Indirizzi:
Innsbruck Univ, Dept Radiotherapy & Radiooncol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 oncol, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Magnet Resonance, A-6020 Innsbruck, Austria InnsbruckUniv Innsbruck Austria A-6020 nance, A-6020 Innsbruck, Austria Innsbruck Univ, Depr Radiodiagnost 1, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ost 1, A-6020 Innsbruck, Austria Innsbruck Univ, Inst Histol & Embryol, A-6020 Innsbruck, Austria InnsbruckUniv Innsbruck Austria A-6020 bryol, A-6020 Innsbruck, Austria GSF Forschungszentrum Umwelt & Gesundheit, Inst Radiat Biol, Neuherberg, Germany GSF Forschungszentrum Umwelt & Gesundheit Neuherberg Germany g, Germany
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 217, anno: 2000,
pagine: 385 - 391
SICI:
0033-8419(200011)217:2<385:MOTMDF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREOPERATIVE INFUSIONAL CHEMORADIATION; BLOOD-FLOW; CERVICAL-CANCER; CONTRAST AGENT; NORMAL TISSUE; ADVANCED HEAD; NECK CANCERS; DYNAMIC MRI; RADIOTHERAPY; PERFUSION;
Keywords:
magnetic resonance (MR), contrast enhancement; magnetic resonance (MR), inversion recovery; magnetic resonance (MR), perfusion study; pelvic organs, MR; pelvic organs, therapeutic radiology; rectum, neoplasms; rectum, therapeutic radiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: de Vries, A Innsbruck Univ, Dept Radiotherapy & Radiooncol, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 , Austria
Citazione:
A. de Vries et al., "Monitoring of tumor microcirculation during fractionated radiation therapyin patients with rectal carcinoma: Preliminary results and implications for therapy", RADIOLOGY, 217(2), 2000, pp. 385-391

Abstract

PURPOSE: To measure microcirculatory changes during chemoirradiation and to correlate perfusion index (Pi) values with therapy outcome. MATERIALS AND METHODS: Perfusion data in 11 patients with cT3 (clinical staging, tumor invaded the perirectal tissue) rectal carcinoma who underwent preoperative chemoirradiation were analyzed. Perfusion data were acquired by using a T1 mapping sequence with a whole-body magnetic resonance (MR) imager. After contrast medium was intravenously infused at a constant rate, concentration-and-time curves were evaluated for arterial blood and tumor. All patients underwent MR imaging before and at constant intervals during chemoirradiation. Clinical stages before therapy were compared with surgical stages after therapy. RESULTS: Spatial and temporal resolution on dynamic fl maps were sufficient to reveal changes in contrast medium accumulation in the tumor. Comparison of PI values and radiation dose showed a significant increase in the ist (P = .003) and 2nd weeks (P = .01) of treatment; values subsequently returned to pretreatment levels or showed a renewed increase. High initial PI values correlated with greater lymph node downstaging (P = .042). CONCLUSION: Dynamic T1 mapping provides a suitable tool for monitoring tumor microcirculation during chemoirradiation and offers the potential for individual optimization of therapeutic procedures. Furthermore, these resultsindicate that the PI map may serve as a prognostic factor.

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Documento generato il 02/12/20 alle ore 05:11:20