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Titolo:
Functional switching of GABAergic synapses by ryanodine receptor activation
Autore:
Sun, MK; Nelson, TJ; Alkon, DL;
Indirizzi:
NINDS, Lab Adapt Syst, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 , Lab Adapt Syst, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 22, volume: 97, anno: 2000,
pagine: 12300 - 12305
SICI:
0027-8424(20001024)97:22<12300:FSOGSB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; CA2+ RELEASE CHANNELS; POSTSYNAPTIC POTENTIALS; SYNAPTIC PLASTICITY; PYRAMIDAL CELLS; IN-VITRO; RAT; CALCIUM; NEURONS; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, MK NINDS, Lab Adapt Syst, NIH, Bldg 36,Room 4A24,36 Convent Dr, Bethesda, MD 20892 USA NINDS Bldg 36,Room 4A24,36 Convent Dr Bethesda MD USA 20892 92 USA
Citazione:
M.K. Sun et al., "Functional switching of GABAergic synapses by ryanodine receptor activation", P NAS US, 97(22), 2000, pp. 12300-12305

Abstract

The role of the ryanodine receptor (RyR) in modifiability of synapses madeby the basket interneurons onto the hippocampal CA1 pyramidal cells was examined in rats. Associating single-cell RyR activation with postsynaptic depolarization increased intracellular free Ca2+ concentrations and reversed the basket interneuron-CA1 inhibitory postsynaptic potential into an excitatory postsynaptic potential. This synaptic transformation was accompanied by a shift of the reversal potential from that of chloride toward that of bicarbonate, This inhibitory postsynaptic potential-excitatory postsynaptic potential transformation was prevented by blocking RyR or carbonic anhydrase. Associated postsynaptic depolarization and RyR activation, therefore, changes GABAergic synapses from excitation filters to amplifier and, thereby, shapes information flow through the hippocampal network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:55:10