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Titolo:
Prostate formation in a marsupial is mediated by the testicular androgen 5alpha-androstane-3 alpha,17 beta-diol
Autore:
Shaw, G; Renfree, MB; Leihy, MW; Shackleton, CHL; Roitman, E; Wilson, JD;
Indirizzi:
Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA Childrens Hosp Oakland Oakland CA USA 94609 s Inst, Oakland, CA 94609 USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 r, Dept Internal Med, Dallas, TX 75390 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 22, volume: 97, anno: 2000,
pagine: 12256 - 12259
SICI:
0027-8424(20001024)97:22<12256:PFIAMI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPOSSUM MONODELPHIS-DOMESTICA; SEXUAL-DIFFERENTIATION; TAMMAR WALLABY; POSTNATAL-DEVELOPMENT; MASS-SPECTROMETRY; MACROPUS-EUGENII; POUCH YOUNG; PLASMA; RAT; DIHYDROTESTOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, JD Univ Melbourne, Dept Zool, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 ic 3010, Australia
Citazione:
G. Shaw et al., "Prostate formation in a marsupial is mediated by the testicular androgen 5alpha-androstane-3 alpha,17 beta-diol", P NAS US, 97(22), 2000, pp. 12256-12259

Abstract

Development of the male urogenital tract in mammals is mediated by testicular androgens. It has been tacitly assumed that testosterone acts through its intracellular metabolite dihydrotestosterone (DHT) to mediate this process, but levels of these androgens are not sexually dimorphic in plasma at the time of prostate development. Here we show that the 3 alpha -reduced derivative of DHT, 5 alpha -androstane-3 alpha ,17 beta -diol (5 alpha -adiol), is formed in testes of tammar wallaby pouch young and is higher in male than in female plasma in this species during early sexual differentiation. Administration of 5 alpha -adiol caused formation of prostatic buds in female wallaby pouch young, and in tissue minces of urogenital sinus and urogenital tubercle radioactive 5 alpha -adiol was converted to DHT, suggesting that circulating 5 alpha -adiol acts through DHT in target tissues. We conclude that circulating 5 alpha -adiol is a key hormone in male development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:05:26