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Titolo:
Eptastigmine restores the aged rat's normal cortical spectral power pattern
Autore:
Braida, D; Ottonello, F; Sala, M;
Indirizzi:
Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, I-20129 Milan, Italy Univ Milan Milan Italy I-20129 erapy & Med Toxicol, I-20129 Milan, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 42, anno: 2000,
pagine: 495 - 500
SICI:
1043-6618(200011)42:5<495:ERTARN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINESTERASE-INHIBITORS; CHOLINERGIC NEURONS; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; NEOCORTICAL EEG; METRIFONATE; ACETYLCHOLINE; PERFORMANCE; MODULATION; VIGILANCE;
Keywords:
acetylcholinesterase inhibitor; eptastigmine; electroencephalogram; spontaneous motor activity; young vs aged rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sala, M Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan Italy I-20129 129 Milan, Italy
Citazione:
D. Braida et al., "Eptastigmine restores the aged rat's normal cortical spectral power pattern", PHARMAC RES, 42(5), 2000, pp. 495-500

Abstract

We studied the ability of eptastigmine, a second-generation acetylcholinesterase inhibitor (AChEI), to reverse the age-related increase of electroencephalogram (EEG) mean cortical spectral power in slow-wave delta activity and decrease in fast-wave alpha and beta activity. The relative basal spectral power profile evaluated for 50 min of the old (27-30 months) in comparison to young (4-6 months) awake rats was consistently different, showing a significant increase in delta (0.2-4.0 Hz) frequency and a significant decrease of alpha (8.2-13.0 Hz) and beta (13.2-25.0) bands. When 0.5, 1, 2, 4 mgkg(-1) of eptastigmine were administered orally as single increasing dosesfor old and young rats 2 h prior to the EEG recordings, lasting 2 h, the relative mean spectral power difference (Delta%) showed a linear log dose-related decrease in 6 activity and a progressive increase in a and beta activity in old rats. Compared to vehicle, in young rats, the eptastigmine dose of 0.5 mg kg(-1) produced a significant decrease in 6 activity and an increase in beta activity. The spontaneous motor activity, evaluated through cumulative horizontal and vertical counts for 30 min in old rats was significantly decreased when compared to young rats. Single oral treatment with eptastigmine (0.5 mg kg(-1) for young and 2 mg kg(-1) for old rats) given 2 h before the test did not significantly change motor activity in comparison tovehicle group of the same age. These results suggest a possible strategy to alleviate the severe slowing of neocortical EEG accompanying the cognitive decline. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:15:58