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Titolo:
New aspects on the melanocortins and their receptors
Autore:
Wikberg, JES; Muceniece, R; Mandrika, I; Prusis, P; Lindblom, J; Post, C; Skottner, A;
Indirizzi:
Uppsala Univ, Dept Pharmaceut Biosci, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 ut Biosci, SE-75124 Uppsala, Sweden Melacure Therapeut AB, SE-75183 Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden SE-75183 , SE-75183 Uppsala, Sweden
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 5, volume: 42, anno: 2000,
pagine: 393 - 420
SICI:
1043-6618(200011)42:5<393:NAOTMA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING-HORMONE; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; EXPERIMENTAL BRAIN INFLAMMATION; PEPTIDES INHIBIT PRODUCTION; PROOPIOMELANOCORTIN-DERIVED PEPTIDES; PROLONGED RESPIRATORY ARREST; AGOUTI OBESITY SYNDROME; PITUITARY-ADRENAL-AXIS; VENTRAL TEGMENTAL AREA;
Keywords:
melanocortin; melanocortin receptor; melanoma; immune system; cardiovascular effects; behavioural effects; feeding behaviour; neuroendocrine effects;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
272
Recensione:
Indirizzi per estratti:
Indirizzo: Wikberg, JES Pharmaceut Pharmacol, Box 591,BMC, SE-75124 Uppsala, Sweden Pharmaceut Pharmacol Box 591,BMC Uppsala Sweden SE-75124 den
Citazione:
J.E.S. Wikberg et al., "New aspects on the melanocortins and their receptors", PHARMAC RES, 42(5), 2000, pp. 393-420

Abstract

Knowledge of melanocortins and their receptors has increased tremendously over the last few years. The cloning of five melanocortin receptors, and the discovery of two endogenous antagonists for these receptors, agouti and agouti-related peptide, have sparked intense interest in the field. Here we give a comprehensive review of the pharmacology, physiology and molecular biology of the melanocortins and their receptors. In particular, we review the roles of the melanocortins in the immune system, behaviour, feeding, thecardiovascular system and melanoma. Moreover, evidence is discussed suggesting that while many of the actions of the melanocortins are mediated via melanocortin receptors, some appear to be mediated via mechanisms distinct from melanocortin receptors. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 03:30:28