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Titolo:
Expression of intrapulmonary surfactant apoprotein-A in autopsied lungs: Comparative study of cases with or without pulmonary hypoplasia
Autore:
Minowa, H; Takahashi, Y; Kawaguchi, C; Sadou, T; Konishi, N; Nishikubo, T; Yoshioka, A;
Indirizzi:
Nara Med Univ Hosp, Dept Pediat, Div Neonatal Intens Care, Kashihara, Nara, Japan Nara Med Univ Hosp Kashihara Nara Japan ens Care, Kashihara, Nara, Japan Nara Med Univ Hosp, Dept Pathol 2, Kashihara, Nara, Japan Nara Med Univ Hosp Kashihara Nara Japan Pathol 2, Kashihara, Nara, Japan Nara Prefectural Nara Hosp, Perinatal Med Ctr, Neonatal Intens Care Unit, Nara, Nara, Japan Nara Prefectural Nara Hosp Nara Nara Japan Care Unit, Nara, Nara, Japan
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 5, volume: 48, anno: 2000,
pagine: 674 - 678
SICI:
0031-3998(200011)48:5<674:EOISAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL ALVEOLAR COUNT; IMMUNOHISTOCHEMICAL DISTRIBUTION; DIAPHRAGMATIC-HERNIA; PROTEIN-A; DIAGNOSIS; INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, Y Nara Med Univ Hosp, Dept Pediat, Div Neonatal Intens Care, 840 Shijocho, Kashihara, Nara, Japan Nara Med Univ Hosp 840 Shijocho Kashihara Nara Japan , Japan
Citazione:
H. Minowa et al., "Expression of intrapulmonary surfactant apoprotein-A in autopsied lungs: Comparative study of cases with or without pulmonary hypoplasia", PEDIAT RES, 48(5), 2000, pp. 674-678

Abstract

To investigate the functional maturity of the lungs of infants with pulmonary hypoplasia, we measured the expression of surfactant apoprotein-A (SP-A) in the autopsied lungs. Autopsied lungs were taken from 16 infants who died at birth or soon after. A lung-to-body weight ratio of less than 1.2% was defined as pulmonary hypoplasia. Eight infants were classified as belonging to the normal group, and eight as belonging to the pulmonary hypoplasia group. Many of the pulmonary hypoplasia group were complicated not only by pulmonary hypoplasia, but also by amniotic fluid volume abnormalities or ananatomical malformation. We measured the expression of SP-A immunologically using murine anti-human SP-A MAb in the autopsied lung tissue, and subjected the tissue to SP-A staining by the direct staining method. The expression of SP-A was assessed as one of four grades: -, +/-, 1+, 2+. The stainingintensity of SP-A was high at if or stronger in five infants of the normalgroup. SP-A expression was significantly reduced, however, in all infants of the pulmonary hypoplasia group except for one infant with normal amniotic fluid volume and relatively mild pulmonary hypoplasia. There was a significant negative correlation between the staining intensity of SP-A and two factors: pulmonary hypoplasia and abnormal amniotic fluid volume (p = 0.039 and p = 0.0063, respectively). In the present study, we demonstrated that SP-A expression was significantly reduced in infants with pulmonary hypoplasia. We speculate that the functional maturity of the lungs of infants with pulmonary hypoplasia is also suppressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:35:44