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Titolo:
A rat model for investigation of bladder dysfunction associated with demyelinating disease resembling multiple sclerosis
Autore:
Mizusawa, H; Igawa, Y; Nishizawa, O; Ichikawa, M; Ito, M; Andersson, KE;
Indirizzi:
Univ Lund Hosp, Dept Clin Pharmacol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Clin Pharmacol, S-22185 Lund, Sweden Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 rol, Matsumoto, Nagano 390, Japan Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 iat, Matsumoto, Nagano 390, Japan Shinshu Univ, Sch Med, Dept Pathol, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 hol, Matsumoto, Nagano 390, Japan
Titolo Testata:
NEUROUROLOGY AND URODYNAMICS
fascicolo: 6, volume: 19, anno: 2000,
pagine: 689 - 699
SICI:
0733-2467(2000)19:6<689:ARMFIO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; URINARY-TRACT DYSFUNCTION; ABNORMALITIES;
Keywords:
myelin basic protein; experimental allergic encephalomyelitis; cystometry; bladder overactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mizusawa, H Univ Lund Hosp, Dept Clin Pharmacol, S-22185 Lund, Sweden UnivLund Hosp Lund Sweden S-22185 col, S-22185 Lund, Sweden
Citazione:
H. Mizusawa et al., "A rat model for investigation of bladder dysfunction associated with demyelinating disease resembling multiple sclerosis", NEUROUROL U, 19(6), 2000, pp. 689-699

Abstract

Myelin basic protein (MBP) can be used as an antigen for inducing experimental allergic encephalomyelitis (EAE). In various studies, EAE animals havebeen used as an experimental model of demyelinating diseases. The aim of this study was to determine whether EAE, induced by MBP in rats, can be useful for investigation of bladder dysfunction associated with demyelinating disease. Female Lewis rats were used. In Study 1, the time course of behavioral and cystometric changes were observed consecutively after MBP sensitization. In Study 2, the correlations between behavioral, cystometric. and histologic abnormalities were studied. The degree of paralysis and histologic findings were evaluated. In Study 1, transient hind limb paralysis was observed in all rats. Cystometric findings were characterized by three different patterns: 1) detrusor areflexia (DA), 2) detrusor hyperactivity (DH), and3) normal. Ten (77%) of the 13 rats given MBP showed bladder dysfunction, including DA (seven), DA/DH (two) and DH tone). Study 2 showed DA in 10 rats, DH in one, and normal findings in nine animals. The difference in degreeof paralysis between the DA and the cystometrically normal animals was statistically significant (P < 0.01). The mean value of the degree of inflammation in the spinal cord (L6-S1) in the DA group was significantly (P < 0.05) higher than that in the cystometrically normal group. The degrees of paralysis and spinal inflammation were weakly con elated (R = 0.47, P = 0.05). The present rat model seems useful for studies of bladder dysfunction associated with spinal myelitis/demyelinating diseases. (C) 2000 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:07:07