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Titolo:
Inhibition of nociceptive withdrawal reflex by microinjection of interleukin 2 into rat locus coeruleus
Autore:
Guo, H; Zhao, ZQ;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Physiol, Key Lab Neurobiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
NEUROPEPTIDES
fascicolo: 3-4, volume: 34, anno: 2000,
pagine: 216 - 220
SICI:
0143-4179(200006/08)34:3-4<216:IONWRB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL RETICULAR NUCLEUS; SPINAL INHIBITION; CERULEUS; BRAIN; STIMULATION; EXPRESSION; YOHIMBINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, ZQ Chinese Acad Sci, Shanghai Inst Physiol, Key Lab Neurobiol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China Chinese Acad Sci 320 Yue Yang Rd Shanghai Peoples R China 200031
Citazione:
H. Guo e Z.Q. Zhao, "Inhibition of nociceptive withdrawal reflex by microinjection of interleukin 2 into rat locus coeruleus", NEUROPEPTID, 34(3-4), 2000, pp. 216-220

Abstract

This study was to examine the effects of microinjection of human recombinant interleukin 2 (IL-2) into locus coeruleus (tc) on spinal nociception. Following application of IL-2 (0.1 mul, 10 pM) into LC, the percentage of inhibition of nociceptive C responses of reflex at 3, 9, 15, 21 and 27 min after injection were 88.2 +/- 9.4%, 84.0 +/- 11.8%, 89.7 +/- 10.5%, 57.1 +/- 8.7% and 26.3 +/- 12.2%, respectively. Also, the expression of Fos protein in superficial dorsal horn was reduced by 73.01 +/- 13.58% of control (P<0.0001). Naloxone (10 <mu>g, i.p.) completely blocked the IL-2-induced inhibition of C responses. The results clearly show that IL-2 receptors present inLC mediate descending inhibition of the spinal nociception, which may couple with the activation of opioid receptors on LC neurons. (C) 2000 HarcourtPublishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:17:13