Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of melanocortin receptors in sexual behavior in female rats
Autore:
Cragnolini, A; Scimonelli, T; Celis, ME; Schioth, HB;
Indirizzi:
Uppsala Univ, Dept Neurosci, Uppsala, Sweden Uppsala Univ Uppsala Sweden ppsala Univ, Dept Neurosci, Uppsala, Sweden Melacure Therapeut AB, Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden cure Therapeut AB, Uppsala, Sweden Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, Lab Fisiol, RA-5000 Cordoba, Argentina Univ Nacl Cordoba Cordoba Argentina RA-5000 , RA-5000 Cordoba, Argentina
Titolo Testata:
NEUROPEPTIDES
fascicolo: 3-4, volume: 34, anno: 2000,
pagine: 211 - 215
SICI:
0143-4179(200006/08)34:3-4<211:TROMRI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; RADIOLIGAND BINDING; MSH ANALOGS; EXPRESSION; ANTAGONIST; ALPHA; BRAIN; MELANOTROPIN; SELECTIVITY; PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Schioth, HB Biomed Ctr, Dept Neurosci, Box 593, S-75124 Uppsala, Sweden Biomed Ctr Box 593 Uppsala Sweden S-75124 124 Uppsala, Sweden
Citazione:
A. Cragnolini et al., "The role of melanocortin receptors in sexual behavior in female rats", NEUROPEPTID, 34(3-4), 2000, pp. 211-215

Abstract

Earlier data have indicated that a-MSH may play a role for sexual behaviorin rats. In this study we investigated the effects of MSH peptides on sexual receptivity in Qvariectomized-adrenalectomized female rats, pretreated with benzoate of estradiol, in presence of vigorous male rats. The results show that alpha -MSH significantly increases lordosis behavior in female rats after injections into the ventromedial nucleus. Interestingly, we have for the first time shown that gamma -MSH also causes significant increase in lordosis in female rats. Furthermore, we show that HS014, an antagonist forthe central MC receptors, in dose dependent manner blocks the effect of alpha -MSH on lordosis. The results indicate that the effects of MSH peptideson female sexual behaviour are mediated through a specific MC receptor, which could be the MC3 receptor. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 19:02:07