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Titolo:
Evidence for cortical coding of saccade velocity in memory-guided saccadesin patients with CADASIL
Autore:
Straube, A; Mayer, M; Eggert, T; Ditterich, J;
Indirizzi:
Univ Munich, Dept Neurol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 h, Dept Neurol, D-8000 Munich, Germany
Titolo Testata:
NEURO-OPHTHALMOLOGY
fascicolo: 1, volume: 24, anno: 2000,
pagine: 291 - 299
SICI:
0165-8107(2000)24:1<291:EFCCOS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL EYE-FIELD; AUTOSOMAL-DOMINANT ARTERIOPATHY; SUPERIOR COLLICULUS; SUBCORTICAL INFARCTS; VOLUNTARY SACCADES; MOVEMENTS; LESIONS; LEUKOENCEPHALOPATHY; DEFICITS;
Keywords:
saccade dynamics; memory-guided saccades; visually guided saccades; saccadic burst generator; CADASIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Straube, A Univ Munich, Klinikum Grosshadern, Dept Neurol, Marchioninistr 15, D-81377Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
A. Straube et al., "Evidence for cortical coding of saccade velocity in memory-guided saccadesin patients with CADASIL", NEURO-OPHTH, 24(1), 2000, pp. 291-299

Abstract

Saccadic eye movements were elicited in ten patients with CADASIL (an autosomal dominant cerebral angiopathy) and ten age-matched controls under six different conditions: 1) the gap paradigm, which tests visually guided, reflexive saccades; 2) the overlap paradigm; 3 and 4) the anti-gap and anti-overlap paradigms, which are thought to test especially the function of the frontal cortex; 5) the memory paradigm, which tests internally guided, intentional saccades; and 6) the sequential memory-guided saccades. Eye movements were recorded by means of DC electro-oculography, and the saccade latency, gain, duration, and peak eye velocity were estimated. The amplitude-to-duration as well as the amplitude-to-peak velocity ratios were calculated forboth groups and conditions 1 and 5. There were no significant differences in the gains of the primary saccades in the gap, overlap, and memory paradigms. In general, the CADASIL patients showed a tendency toward longer saccade latencies and a larger number of unwanted saccades in the antitask saccade and memory saccade paradigms (suppression errors). Our main finding was that the patients had a highly significant reduction in peak velocity and acorresponding prolongation of the duration of the memory-guided saccades compared to the controls. In contrast, the duration and the peak velocity ofthe visually guided saccades did not differ between controls and patients. Thus, we observed a specific change in he dynamic properties of memory-guided saccades in CADASIL patients. The observed pattern of saccade abnormalities in the CADASIL patients does not allow localization to a specific cortical side; however, it might reflect the presence of a mostly frontal type of lesion. This finding contradicts the view that information passed from the cortex to the brainstem codes only the saccade vector and not saccade dynamics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:19:01