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Titolo:
Interactions between methadone and medications used to treat HIV infection: A review
Autore:
Gourevitch, MN; Friedland, GH;
Indirizzi:
Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat, Bronx, NY USAMontefiore Med Ctr Bronx NY USA n Coll Med, Dept Psychiat, Bronx, NY USA Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 Med, Dept Med, Bronx, NY 10467 USA Montefiore Med Ctr, Albert Einstein Coll Med, Dept Epidemiol & Social Med,Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 ol & Social Med,Bronx, NY 10467 USA Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA Yale Univ New HavenCT USA 06510 h Med, Dept Med, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 iol & Publ Hlth, New Haven, CT 06510 USA
Titolo Testata:
MOUNT SINAI JOURNAL OF MEDICINE
fascicolo: 5-6, volume: 67, anno: 2000,
pagine: 429 - 436
SICI:
0027-2507(200010/11)67:5-6<429:IBMAMU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-USERS; PROTEASE INHIBITORS; CYTOCHROME-P450 3A4; LIVER-MICROSOMES; METABOLISM; WITHDRAWAL; PHARMACOKINETICS; ZIDOVUDINE;
Keywords:
methadone; antiretroviral therapy; interactions; HIV; medications; pharmacotherapies; pharmacodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gourevitch, MN AECOM, Div Subst Abuse, 1500 Waters Pl,Parker Bldg 6th Floor Ward 20, Bronx, NY 10461 USA AECOM 1500 Waters Pl,Parker Bldg 6th Floor Ward 20 Bronx NY USA 10461
Citazione:
M.N. Gourevitch e G.H. Friedland, "Interactions between methadone and medications used to treat HIV infection: A review", MT SINAI J, 67(5-6), 2000, pp. 429-436

Abstract

Background: It is critical for providers caring for HIV-positive methadonerecipients to have accurate information on pharmacologic interactions between methadone and antiretroviral therapy. If providers do not have these data, symptoms of narcotic withdrawal or excess due to medication interactions may be mismanaged, and antiretroviral regimens may be suboptimal in efficacy or associated with increased side effects and toxicities. This review was undertaken to clarify what is known about interactions between pharmacotherapies of opiate dependence and HIV-related medications, to suggest clinically useful approaches to these issues, and to outline areas which need further study. Methods: A search for relevant published papers and abstracts presented atscientific meetings was conducted using electronic databases. These documents were obtained and reviewed, and additional publications referenced in them were also reviewed. Results: Pharmacokinetic interactions between methadone and zidovudine, didanosine, stavudine, abacavir, nevirapine, efavirenz and nelfinavir have been documented. The mechanisms, clinical implications and management of these interactions are reviewed. Conclusions: Interactions between methadone and some HIV-related medications are known to occur, yet their characteristics cannot reliably be predicted based on current understanding of metabolic enzyme induction and inhibition, or through in vitro studies. Only carefully designed and conducted pharmacologic studies involving human subjects can help us define the nature of the interactions between methadone land other pharmacotherapies for opiate dependence) and specific HIV-related medications. Clinicians must be aware of known interactions and be alert to the possibility that interactions which are still undocumented may be present among their patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:09