Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain
Autore:
Dowling, ALS; Zoeller, RT;
Indirizzi:
Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 Dept Biol, Amherst, MA 01003 USA Univ Massachusetts, Mol & Cellular Biol Program, Morrill Sci Ctr, Amherst,MA 01003 USA Univ Massachusetts Amherst MA USA 01003 ill Sci Ctr, Amherst,MA 01003 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 82, anno: 2000,
pagine: 126 - 132
SICI:
0169-328X(20001020)82:1-2<126:THOMOR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-C SUBSTRATE; MYELIN BASIC-PROTEIN; MESSENGER-RNA; NEONATAL-HYPOTHYROIDISM; GENE-EXPRESSION; RECEPTOR; NEUROGRANIN; PHOSPHORYLATION; DEFICIENCY; PREGNANCY;
Keywords:
thyroid hormone; RC3/neurogranin; brain development; cerebral cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Zoeller, RT Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 Amherst, MA 01003 USA
Citazione:
A.L.S. Dowling e R.T. Zoeller, "Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain", MOL BRAIN R, 82(1-2), 2000, pp. 126-132

Abstract

Recent clinical studies indicate that thyroid hormone plays essential roles in fetal brain development. However, the mechanism by which thyroid hormone affects fetal brain development is poorly studied. We recently identified several genes expressed in the fetal cortex whose abundance is affected by thyroid hormone of maternal origin. However, it is unclear whether these genes are directly regulated by thyroid hormone. Because these are the first genes known to be regulated by thyroid hormone during fetal development, we sought to expand our investigation to genes known to be regulated directly by thyroid hormone. We now report that the well-known thyroid hormone-responsive gene RC3/neurogranin is expressed in the fetal brain and is regulated by thyroid hormone of maternal origin. These findings support the concept that maternal thyroid hormone exerts a direct action on the expression of genes in the fetal brain that are important for normal neurological development. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:42:57