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Titolo:
Gene bet1 involved in vesicular transport is differentially transcribed intransformed cells of different metastatic potential
Autore:
Chepurnykh, TV; Shtutman, MS; Bykova, AV; Yanushevich, YG; Tatosyan, AG;
Indirizzi:
Russian Acad Med Sci, Blokhin Canc Res Ctr, Inst Carcinogenesis, Moscow 115478, Russia Russian Acad Med Sci Moscow Russia 115478 genesis, Moscow 115478, Russia
Titolo Testata:
MOLECULAR BIOLOGY
fascicolo: 5, volume: 34, anno: 2000,
pagine: 772 - 775
SICI:
0026-8933(200009/10)34:5<772:GBIIVT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOPLASMIC-RETICULUM; GOLGI-APPARATUS; SRC ONCOGENE; V-SRC; TUMORIGENICITY; PATHWAYS; PROTEINS; RECEPTOR;
Keywords:
metastasis; v-src; vesicular transport; v-SNARE; Bet1; differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chepurnykh, TV Russian Acad Med Sci, Blokhin Canc Res Ctr, Inst Carcinogenesis, Moscow 115478, Russia Russian Acad Med Sci Moscow Russia 115478 115478, Russia
Citazione:
T.V. Chepurnykh et al., "Gene bet1 involved in vesicular transport is differentially transcribed intransformed cells of different metastatic potential", MOL BIOL, 34(5), 2000, pp. 772-775

Abstract

The method of differential display of cDNA produced on the RNA from highlyand poorly metastasizing cell lines revealed a number of genes with different expression depending on the metastatic potential. An mRNA correspondingto one of these cDNA fragments (7HM) was found in increased amounts in high-metastasis but not in low-metastasis cell lines. The nucleotide sequence of the 7HM fragment showed high homology with that of gene bet1. The Bet1 protein is involved in vesicular transport from the endoplasmic reticulum tothe Golgi complex. Enhanced expression of bet1 in high-metastasis cell lines is probably induced by the oncogene v-src.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 01:55:09