Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain
Autore:
Alvarez-Dolado, M; Cuadrado, A; Navarro-Yubero, C; Sonderegger, P; Furley, AJ; Bernal, J; Munoz, A;
Indirizzi:
Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029,Spain Univ Autonoma Madrid Madrid Spain 28029 Alberto Sols, Madrid 28029,Spain Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 chem, CH-8057 Zurich, Switzerland Univ Sheffield, Dev Genet Programme, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4, volume: 16, anno: 2000,
pagine: 499 - 514
SICI:
1044-7431(200010)16:4<499:ROTLCA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY CALLOSAL CONNECTIONS; SHARED CARBOHYDRATE EPITOPE; TISSUE-SPECIFIC EXPRESSION; LONG-TERM POTENTIATION; GROWTH CONE MOTILITY; MYELIN BASIC-PROTEIN; N-CAM; NEURITE OUTGROWTH; RAT-BRAIN; IMMUNOGLOBULIN SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Alvarez-Dolado, M Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain Univ Autonoma Madrid Arturo Duperier 4 Madrid Spain 28029
Citazione:
M. Alvarez-Dolado et al., "Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain", MOL CELL NE, 16(4), 2000, pp. 499-514

Abstract

Thyroid hormone is essential for brain maturation, regulating neuronal differentiation and migration, myelination, and synaptogenesis. Mutations in the cell adhesion molecule L1 cause severe neurological abnormalities in humans. We studied the effect of thyroid hormone deprivation and administration on L1 expression. Northern and in situ hybridization studies showed that hypothyroidism induces a marked increase in L1 mRNA levels in the caudate putamen, cerebral cortex, amygdala, and some thalamic nuclei. L1 protein wasoverexpressed in embryonic and newborn hypothyroid rats in the caudate putamen, internal capsule, habenula, and neocortex. Later in development, an abnormally high L1 expression was found in the cortical and cerebellar whitematter, corpus callosum, anterior commissure, thalamocortical projections,and striatal fiber tracts of hypothyroid animals. Thyroid hormone administration reversed the upregulation of L1 expression in vivo and in cultured cells. Thus, alterations of L1 expression may contribute to the profound abnormalities caused by hypothyroidism in the developing brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:52:05