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Titolo:
The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes
Autore:
Petersen, JM; Her, LS; Varvel, V; Lund, E; Dahlberg, JE;
Indirizzi:
Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 pt Biomol Chem, Madison, WI 53706 USA
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 22, volume: 20, anno: 2000,
pagine: 8590 - 8601
SICI:
0270-7306(200011)20:22<8590:TMPOVS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY STRUCTURE PREDICTION; REV ACTIVATION DOMAIN; RNA-POLYMERASE-II; IMPORTIN-BETA; EXPORT RECEPTOR; GENE-EXPRESSION; XENOPUS-OOCYTES; IDENTIFICATION; RAN; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Dahlberg, JE Univ Wisconsin, Dept Biomol Chem, 1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin 1300 Univ Ave Madison WI USA 53706 I 53706 USA
Citazione:
J.M. Petersen et al., "The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes", MOL CELL B, 20(22), 2000, pp. 8590-8601

Abstract

The matrix (M) protein of vesicular stomatitis virus (VSV) is a potent inhibitor of bidirectional nuclear transport. Here we demonstrate that inhibition occurs when M protein is in the nucleus of Xenopus laevis oocytes and that M activity is readily reversed by a monoclonal antibody (alphaM). We identify a region of M protein, amino acids 51 to 59, that is required both for inhibition of transport and for efficient recognition by alphaM. When expressed in transfected HeLa cells, M protein colocalizes with nuclear pore complexes (NPCs) at the nuclear rim. Moreover, mutation of a single amino acid, methionine 51, eliminates both transport inhibition and targeting to NPCs. We propose that M protein inhibits bidirectional transport by interacting with a component of the NPC or an NPC-associated factor that participates in nucleocytoplasmic transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:17:16