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Titolo:
Estimating normal and pathological dynamic responses in cerebral blood flow velocity to step changes in end-tidal pCO(2)
Autore:
Simpson, DM; Panerai, RB; Evans, DH; Garnham, J; Naylor, AR; Bell, PRF;
Indirizzi:
Univ Leicester, Fac Med, Div Med Phys, Leicester, Leics, England Univ Leicester Leicester Leics England d Phys, Leicester, Leics, England Queens Med Ctr, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH r, Nottingham NG7 2UH, England Univ Leicester, Fac Med, Div Surg, Leicester, Leics, England Univ Leicester Leicester Leics England v Surg, Leicester, Leics, England
Titolo Testata:
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
fascicolo: 5, volume: 38, anno: 2000,
pagine: 535 - 539
SICI:
0140-0118(200009)38:5<535:ENAPDR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID-ARTERY DISEASE; FREQUENCY-DOMAIN; CARBON-DIOXIDE; AUTOREGULATION; PRESSURE; DOPPLER; HUMANS; CO2; REACTIVITY; OCCLUSIONS;
Keywords:
cerebral blood flow; transcranial Doppler; hypercapnia; optimal filters; autoregulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, DM Univ Leicester, Fac Med, Div Med Phys, Leicester, Leics, England Univ Leicester Leicester Leics England ester, Leics, England
Citazione:
D.M. Simpson et al., "Estimating normal and pathological dynamic responses in cerebral blood flow velocity to step changes in end-tidal pCO(2)", MED BIO E C, 38(5), 2000, pp. 535-539

Abstract

The regulation of cerebral blood flow (CBF) following changes in arterial blood pressure (ABP) and end-tidal pCO(2) (EtCO2) are of clinical interest in assessing cerebrovascular reserve capacity Linear finite-impulse-response modelling is applied to ABP, EtCO2 and CBF velocity (CBFV, from transcranial Doppler measurements), which allows the CBFV response to ideal step changes in EtCO2 to be estimated from clinical data showing more sluggish, andadditional random variations. The confounding effects of ABP changes provoked by hypercapnia on the CBFV are also corrected for. Data from 56 patients suffering from stenosis of the carotid arteries (with normal or diminished cerebrovascular reactivity to EtCO2 changes - CVRCO2) were analysed. The results show the expected significant differences (p<0.05) between EtCO2 steps up and down, the significant contribution from ABP variation, and also differences in the dynamic responses of patients with reduced CVRCO2 (p<0.01 after 10 s). For the latter the CBFV response appears exhausted after about 15 s, whereas for normals CBFV continues to increase. While dispersion of individual step responses remains large, the method gives encouraging results for the non-invasive study of compromised haemodynamics in different patient groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:54:06