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Titolo:
Nerfin-1 and -2, novel Drosophila Zn-finger transcription factor genes expressed in the developing nervous system
Autore:
Stivers, C; Brody, T; Kuzin, A; Odenwald, WF;
Indirizzi:
NINDS, Neurochem Lab, Neurogenet Unit, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Neurogenet Unit, NIH, Bethesda, MD 20892 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 97, anno: 2000,
pagine: 205 - 210
SICI:
0925-4773(200010)97:1-2<205:NA-NDZ>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; NEUROGENESIS;
Keywords:
neuronal precursor gene; pan-neural expression; neural stem cell; neuroblast; ganglion mother cell; CNS and PNS development; transcription factor; EIN Zn-finger domain subfamily;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Odenwald, WF NINDS, Neurochem Lab, Neurogenet Unit, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 nit, NIH, Bethesda, MD 20892 USA
Citazione:
C. Stivers et al., "Nerfin-1 and -2, novel Drosophila Zn-finger transcription factor genes expressed in the developing nervous system", MECH DEVEL, 97(1-2), 2000, pp. 205-210

Abstract

To gain insight into the regulatory networks controlling Drosophila neural-identity decisions, we have identified new neuronal precursor genes by performing an in situ hybridization screen of differentially selected embryonic head cDNAs. Here, we describe the molecular characteristics and expression profile of nerfin-1, a novel pan-neural precursor gene. This paper also documents the embryonic expression of another structurally related gene, nerfin-2. During early CNS development, nerfin-1 gene expression is activated in neuroblasts (NBs) prior to lineage formation. However, after early sublineage development, nerfin-1 expression shifts from NBs to ganglion mother cells (GMCs) but is not expressed in neurons or glia. Differing from nerfin-1, nerfin-2 is expressed only in a subset of brain neurons. Possessing a conserved putative DNA-binding domain, the predicted Nerfin-1 and -2 proteinsbelong to a subfamily of Zn-finger transcription factors with cognates identified in nematode, mouse and man. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:44:23