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Titolo:
Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development
Autore:
Sadek, CM; Jalaguier, S; Feeney, EP; Aitola, M; Damdimopoulos, AE; Pelto-Huikko, M; Gustafsson, JA;
Indirizzi:
Karolinska Inst, Novum, Ctr Biotechnol, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge, Sweden Karolinska Inst, Novum, Dept Med Nutr, S-14157 Huddinge, Sweden KarolinskaInst Huddinge Sweden S-14157 d Nutr, S-14157 Huddinge, Sweden Tampere Univ Hosp, Sch Med, Dept Dev Biol, Tampere 33101, Finland Tampere Univ Hosp Tampere Finland 33101 Dev Biol, Tampere 33101, Finland Tampere Univ Hosp, Dept Pediat, Tampere 33101, Finland Tampere Univ Hosp Tampere Finland 33101 t Pediat, Tampere 33101, Finland Tampere Univ Hosp, Dept Pathol, Tampere 33101, Finland Tampere Univ Hosp Tampere Finland 33101 t Pathol, Tampere 33101, Finland
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 97, anno: 2000,
pagine: 13 - 26
SICI:
0925-4773(200010)97:1-2<13:IACOAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR NUCLEAR TRANSLOCATOR; ARYL-HYDROCARBON RECEPTOR; INDUCIBLE FACTOR 1-ALPHA; TISSUE-SPECIFIC EXPRESSION; UBIQUITIN-PROTEASOME PATHWAY; CLOSE SEQUENCE SIMILARITY; LIGAND-BINDING DOMAIN; AH-RECEPTOR; PAS-DOMAIN; TRANSCRIPTION FACTOR;
Keywords:
basic halix-loop-helix-PAS; bHLH-PAS; Ah receptor nuclear translocator; ARNT; ARNT2; hypoxia; HIF-1 alpha; HLF; NPAS; TACC; coiled-coil; yeast two-hybrid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Sadek, CM Karolinska Inst, Novum, Ctr Biotechnol, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 14157 Huddinge, Sweden
Citazione:
C.M. Sadek et al., "Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development", MECH DEVEL, 97(1-2), 2000, pp. 13-26

Abstract

Basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) proteins form dimeric transcription factors to mediate diverse biological functions including xenobiotic metabolism, hypoxic response, circadian rhythm and central nervous system midline development. The Ah receptor nuclear translocator protein (ARNT) plays a central role as a common heterodimerization partner. Herein, we describe a novel, embryonically expressed, ARNT interacting protein (AINT) that may be a member of a larger coiled-coil PAS interacting protein family. The AINT C-terminus mediates interaction with the PAS domain of ARNT in yeast and interacts in vitro with ARNT and ARNT2 specifically. AINT localizes to the cytoplasm and overexpression leads to non-nuclear localization of ARNT. A dynamic pattern of AINT mRNA expression during embryogenesis and cerebellum ontogeny supports a role for AINT in development. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 22:59:15