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Titolo:
Suppressive effect on tumor metastasis by 6-(methylsulfinyl) hexyl isothiocyanates from Wasabi
Autore:
Fuke, Y; Sawaki, S; Nomura, T; Ryoyama, K;
Indirizzi:
Tokyo Metropolitan Coll, Dept Food Sci & Human Nutr, Akishima, Tokyo 1968540, Japan Tokyo Metropolitan Coll Akishima Tokyo Japan 1968540 Tokyo 1968540, Japan Kanazawa Univ, Canc Res Inst, Dept Mol Oncol, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan Aomori Univ, Fac Engn, Dept Biosci & Biotechnol, Kohata, Aomori 0300943, Japan Aomori Univ Kohata Aomori Japan 0300943 ol, Kohata, Aomori 0300943, Japan
Titolo Testata:
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
fascicolo: 10, volume: 47, anno: 2000,
pagine: 760 - 766
SICI:
1341-027X(2000)47:10<760:SEOTMB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
JPN
Soggetto:
APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Fuke, Y Tokyo Metropolitan Coll, Dept Food Sci & Human Nutr, Akishima, Tokyo 1968540, Japan Tokyo Metropolitan Coll Akishima Tokyo Japan 1968540 68540, Japan
Citazione:
Y. Fuke et al., "Suppressive effect on tumor metastasis by 6-(methylsulfinyl) hexyl isothiocyanates from Wasabi", J JPN SOC F, 47(10), 2000, pp. 760-766

Abstract

A highly metastatic Balb/c mouse cell line, r/m HM-SFME-1, is established from transformed ras/myc SFME cell line carrying active human c-Ha-ras genes. Metastasis was measured by detection of the amount of the PCR products of c-Ha-ras gene from cancer cells which had been inoculated at foot-pad of mice. A standard curve was made using r/m HM SFME-1 cell DNAs. The amount of PCR products corresponding to 123 bp was measured by Bioimage Analyzer. First, we examined the suppressive effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC) against dissemination of tumor cells to kidney of experimental animals at day 9 of inoculation. TNP-470 which has been reported to be effective to the angiogenesis, 4-(methylsulfinyl) butyl isothiocyanate (4-MITC) from broccoli and 6-MITC were administrated to the experimental mice. The 6-MITC of wasabi was more effective than other two chemicals. Then, 6-MITC (40 or 400 muM) was fed orally by mixing with drinking water to examine the suppressive effect of tumor metastasis. No visible alteration of body weight was observed by the administration of 6-MITC. All of the control mice revealed human c-l-la-ras bands. In animals fed 40 muM 6-MITC, ail of the lungs provided human c-Ha-ras bands. Four out of five mice administrated400 muM 6-MITC provided no detectable bands showing no metastasis, however, and only faint band was observable in one mouse lung. Thus, it was suggested that 6-MITC suppressed dissemination or metastasis of tumor cells with oral administration.

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Documento generato il 21/09/20 alle ore 09:43:00