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Titolo:
TREATMENT OF CYTOMEGALOVIRUS RETINITIS WITH A SUSTAINED-RELEASE GANCICLOVIR IMPLANT
Autore:
MUSCH DC; MARTIN DF; GORDON JF; DAVIS MD; KUPPERMANN BD; HEINEMANN MH; CAMPBELL S; BODDICE S; DUKER JS; NAUGHTON K; MCGEARY J; CHONG LP; WALONKER F; LEVIN L; LOPEZ K; GOMES A; DAVIS JL; SIMMONS T; VANDENBROOK R; FISH RH; HUTCHISON C; AI E; LUCKIE A; TASHAYYOD D; ANAND R; CHUANG EL; LAWRENCE B; ROBINSON MR; CHAMPAGNE K; CANTRILL HL; BRALLIER A; FREEMAN WR; JARMAN C; WIELAND MR; COVERSTONE V; LIGH JK; HUTT R; NORMAN BC; CRISTIANO J; NEGER R; CRAWFORD K; WEINBERG DV; MUNANA A; MURPHY FP; PACE B; DUH YJ; GORDON JE; JOHNSON PJ; LEE JA; PANG CF; SAFYAN E; SEIDL NL; STOECKER JF; ASHTON P; SMITH TJ; ARMSTRONG J; BROTHERS R; HUBBARD L; DIETERICH DT; FROST KR; MAGUIRE MG; NUSSENBLATT RB; SANBORN GE;
Indirizzi:
CHIRON VIS INC,9342 JERONIMO RD IRVINE CA 92718 CHIRON VIS INC IRVINE CA 92718 UNIV MICHIGAN,DEPT OPHTHALMOL ANN ARBOR MI 00000 UNIV MICHIGAN,DEPT EPIDEMIOL ANN ARBOR MI 48109 EMORY UNIV,DEPT OPHTHALMOL ATLANTA GA 30322 CHIRON VIS INC,RES & DEV CLAREMONT CA 00000 UNIV WISCONSIN,DEPT OPHTHALMOL MADISON WI 00000 UNIV CALIF IRVINE,DEPT OPHTHALMOL IRVINE CA 92717 CONTROLLED DELIVERY SYST WATERTOWN MA 00000 UNIV WISCONSIN,PUNDUS PHOTOGRAPH READING CTR MADISON WI 00000 NEW YORK UNIV MED NEW YORK NY 00000 AMER FDN AIDS RES ROCKVILLE MD 00000 UNIV PENN PHILADELPHIA PA 19104 NEI BETHESDA MD 20892 UNIV VIRGINIA RICHMOND VA 00000
Titolo Testata:
The New England journal of medicine
fascicolo: 2, volume: 337, anno: 1997,
pagine: 83 - 90
SICI:
0028-4793(1997)337:2<83:TOCRWA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-DEFICIENCY-SYNDROME; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; RHEGMATOGENOUS RETINAL-DETACHMENT; DIHYDROXY PROPOXYMETHYL GUANINE; VIRUS RETINITIS; INTRAVITREAL GANCICLOVIR; AIDS; THERAPY; FOSCARNET; RETINOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Musch et al., "TREATMENT OF CYTOMEGALOVIRUS RETINITIS WITH A SUSTAINED-RELEASE GANCICLOVIR IMPLANT", The New England journal of medicine, 337(2), 1997, pp. 83-90

Abstract

Background Sustained-release, intraocular implants that deliver ganciclovir are an alternative method for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Methods We conducted a randomized study of 188 patients with AIDS and newly diagnosed cytomegalovirus retinitis. The patients were randomly assigned to treatment with an implant delivering 1 mu g of ganciclovir per hour, an implant delivering 2 mu g of ganciclovir per hour, or intravenous ganciclovir. The primary outcome we studied was progression of cytomegalovirus retinitis. Results The median time to progression of retinitis was 221 days with the 1-mu g-per-hour implant (75 eyes), 191 days with the 2-mu g-per-hour implant (71 eyes), and 71 days with ganciclovir administered intravenously (76 eyes; P<0.001). The riskof progression of retinitis was almost three times as great among patients treated with intravenous ganciclovir as among those treated witha ganciclovir implant (risk ratio, 2.8; P<0.001). However, the risk of disease in the initially uninvolved eye was lower with Intravenous ganciclovir than with a ganciclovir implant (risk ratio, 0.5; P=0.19). Patients treated with intravenous ganciclovir were also less likely tohave extraocular cytomegalovirus infections (0, vs. 10.3 percent in the two implant groups; P=0.04). Conclusions For the treatment of cytomegalovirus retinitis, the sustained-release ganciclovir implant is more effective than intravenous ganciclovir, but patients treated with a ganciclovir implant alone remain at greater risk for the development of cytomegalovirus disease outside of the treated eye. (C) 1997, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:18:33