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Titolo:
TRIAL OF CALCIUM TO PREVENT PREECLAMPSIA
Autore:
LEVINE RJ; HAUTH JC; CURET LB; SIBAI BM; CATALANO PM; MORRIS CD; DERSIMONIAN R; ESTERLITZ JR; RAYMOND EG; BILD DE; CLEMENS JD; CUTLER JA;
Indirizzi:
NICHHD,DIV EPIDEMIOL STAT & PREVENT RES,BLDG 6100,RM 7B03 BETHESDA MD20892 UNIV ALABAMA,DEPT OBSTET & GYNECOL BIRMINGHAM AL 35294 UNIV NEW MEXICO,HLTH SCI CTR,DEPT OBSTET & GYNECOL ALBUQUERQUE NM 87131 UNIV TENNESSEE,COLL MED,DEPT OBSTET & GYNECOL MEMPHIS TN 00000 CASE WESTERN RESERVE UNIV,METROHLTH MED CTR,DEPT OBSTET & GYNECOL CLEVELAND OH 00000 OREGON HLTH SCI UNIV,DEPT MED PORTLAND OR 97201 EMMES CORP POTOMAC MD 00000 FAMILY HLTH INT RES TRIANGLE PK NC 27709 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892
Titolo Testata:
The New England journal of medicine
fascicolo: 2, volume: 337, anno: 1997,
pagine: 69 - 76
SICI:
0028-4793(1997)337:2<69:TOCTPP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY-INDUCED HYPERTENSION; SUPPLEMENTATION; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Levine et al., "TRIAL OF CALCIUM TO PREVENT PREECLAMPSIA", The New England journal of medicine, 337(2), 1997, pp. 69-76

Abstract

Background Previous trials have suggested that calcium supplementation during pregnancy may reduce the risk of preeclampsia. However, differences in study design and a low dietary calcium intake in the populations studied limit acceptance of the data. Methods We randomly assigned 4589 healthy nulliparous women who were 13 to 21 weeks pregnant to receive daily treatment with either 2 g of elemental calcium or placebofor the remainder of their pregnancies. Surveillance for preeclampsiawas conducted by personnel unaware of treatment-group assignments, using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits, protocols for monitoring these measurements during the hospitalization for delivery, and reviews of medical records of unscheduled outpatient visits and all hospitalizations. Results Calcium supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. Preeclampsia occurred in 158 of the 2295 women in the calcium group (6.9 percent) and 168 of the 2294 women in the placebo group (7.3 percent) (relative risk, 0.94; 95 percent confidence interval, 0.76 to 1.16). There were no significant differences between the two groups in the prevalence of pregnancy-associated hypertension without preeclampsia (15.3percent vs. 17.3 percent) or of all hypertensive disorders (22.2 percent vs. 24.6 percent). The mean systolic and diastolic blood pressuresduring pregnancy were similar in both groups. Calcium did not reduce the numbers of preterm deliveries, small-for-gestational-age births, or fetal and neonatal deaths; nor did it increase urolithiasis during pregnancy. Conclusions Calcium supplementation during pregnancy did notprevent preeclampsia, pregnancy-associated hypertension, or adverse perinatal outcomes in healthy nulliparous women. (C) 1997, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:52:27