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Titolo:
Preparation and pharmacokinetic evaluation of iodine-125 labeled alphamethyl-L-tyrosine
Autore:
Korde, A; Venkatesh, M; Sarma, HD; Pillai, MRA;
Indirizzi:
Bhabha Atom Res Ctr, Radiopharmaceut Div, Bombay 400085, Maharashtra, India Bhabha Atom Res Ctr Bombay Maharashtra India 400085 5, Maharashtra, India Bhabha Atom Res Ctr, Div Radiat Biol, Bombay 400085, Maharashtra, India Bhabha Atom Res Ctr Bombay Maharashtra India 400085 5, Maharashtra, India
Titolo Testata:
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
fascicolo: 1, volume: 246, anno: 2000,
pagine: 173 - 178
SICI:
0236-5731(200010)246:1<173:PAPEOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-3-IODO-ALPHA-METHYL TYROSINE; BRAIN-TUMORS; AMINO-ACIDS; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Korde, A Bhabha Atom Res Ctr, Radiopharmaceut Div, Bombay 400085, Maharashtra, India Bhabha Atom Res Ctr Bombay Maharashtra India 400085 shtra, India
Citazione:
A. Korde et al., "Preparation and pharmacokinetic evaluation of iodine-125 labeled alphamethyl-L-tyrosine", J RAD NUCL, 246(1), 2000, pp. 173-178

Abstract

Cerebral amino acid metabolism is known to be associated with various psychosomatic disorders. 3-(I-123)iodo-L-alpha methyl tyrosine I-123-L-AMT is an alternative to the PET radiopharmaceutical, C-11-thymidine, for brain SPECT studies. Radioiodination of L-alphamethyl tyrosine using chloramine T aswell as iodogen has been standardized using I-125 as the first step towards the development of the SPECT imaging agent (123)-I-L-AMT. Purification ofthe iodinated product was carried out over Sephadex LH-20 column. A quick and easy purification method using Sep-pak column also has been standardized. Quality control of the I-125-L-AMT was carried out by estimating the radiochemical purity and stability of the product. Biodistribution studies of the product were carried out in mice. Time dependent pharmacokinetic studies and activity distribution pattern in the different parts of the brain were also carried out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 07:14:26