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Titolo:
The in vitro ethanol sensitivity of hippocampal synaptic gamma-aminobutyric acid(A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol
Autore:
Poelchen, W; Proctor, WR; Dunwiddie, TV;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pharmacol C236, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 pt Pharmacol C236, Denver, CO 80262 USA Dept Vet Affairs Med Ctr, Denver, CO USA Dept Vet Affairs Med Ctr Denver CO USA t Affairs Med Ctr, Denver, CO USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 2, volume: 295, anno: 2000,
pagine: 741 - 746
SICI:
0022-3565(200011)295:2<741:TIVESO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; ACTIVATED CHLORIDE CHANNELS; RECEPTOR-MEDIATED RESPONSES; CA1 PYRAMIDAL NEURONS; PROTEIN-KINASE-C; GABA(A) RECEPTORS; LONG-SLEEP; MOUSE HIPPOCAMPAL; CORTICAL-NEURONS; ION CHANNELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Dunwiddie, TV Univ Colorado, Hlth Sci Ctr, Dept Pharmacol C236, 4200 E 9thAve, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262O 80262 USA
Citazione:
W. Poelchen et al., "The in vitro ethanol sensitivity of hippocampal synaptic gamma-aminobutyric acid(A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol", J PHARM EXP, 295(2), 2000, pp. 741-746

Abstract

Previous work has demonstrated that in the hippocampal CA1 region of Sprague-Dawley rats, there are ethanol-sensitive and ethanol-insensitive populations of GABAergic synapses on pyramidal neurons. The present experiments characterized the ethanol sensitivity of these pathways in lines of rats and mice genetically selected for sensitivity or insensitivity to the behavioral effects of ethanol. In ethanol-sensitive inbred long sleep mice, GABA(A) IPSCs induced by stimulation of proximal (probably somatic) synapses were enhanced by 80 mM ethanol, whereas the distal (i.e., dendritic) pathway was unaffected. Thus, the relative sensitivity of these pathways (proximal. distal) is the same in both Sprague-Dawley rats and in inbred long sleep mice. However, in the ethanol-insensitive inbred short sleep mice, neither proximal nor distal IPSCs were affected by 80 mM ethanol. The ethanol sensitivity of the proximal pathway was also examined in replicate lines of rats selected for either high ethanol sensitivity or low ethanol sensitivity. GABA(A) IPSCs in the high ethanol sensitivity lines were significantly enhanced by 80 mM ethanol, whereas IPSCs in the low ethanol sensitivity lines were unaffected. Thus, IPSCs evoked via the proximal pathway were enhanced by ethanol in all the sensitive mouse and rat lines, and unaffected in all the insensitive lines. These experiments demonstrate that GABA(A) synapses in brain differ in their sensitivity to enhancement by ethanol, and the sensitivity to such enhancement is under the control of genes that can be selected for using classical genetic selective breeding based on a behavioral phenotype.

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Documento generato il 04/04/20 alle ore 02:56:38