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Titolo:
Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning
Autore:
Schafe, GE; Atkins, CM; Swank, MW; Bauer, EP; Sweatt, JD; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn, Neurobiol Lab, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn, Neurobiol Lab, New York, NY 10003 USA Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Div Neurosci, Houston, TX 77030 USA Cornell Univ, Med Ctr, Dept Psychiat, White Plains, NY 10605 USA Cornell Univ White Plains NY USA 10605 ychiat, White Plains, NY 10605 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 20, anno: 2000,
pagine: 8177 - 8187
SICI:
0270-6474(20001101)20:21<8177:AOEKIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; ELEMENT-BINDING PROTEIN; MAP KINASE; SYNAPTIC PLASTICITY; IN-VITRO; POTENTIATION; PKA; CREB; CASCADE; LTP;
Keywords:
amygdala; fear conditioning; ERK; MAPK; learning; LTP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Schafe, GE NYU, Ctr Neural Sci, WM Keck Fdn, Neurobiol Lab, 4 Washington Pl,Room 809,New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
G.E. Schafe et al., "Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning", J NEUROSC, 20(21), 2000, pp. 8177-8187

Abstract

Although much has been learned about the neurobiological mechanisms underlying Pavlovian fear conditioning at the systems and cellular levels, relatively little is known about the molecular mechanisms underlying fear memory consolidation. The present experiments evaluated the role of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling cascade in the amygdala during Pavlovian fear conditioning. We firstshow that ERK/MAPK is transiently activated-phosphorylated in the amygdala, specifically the lateral nucleus (LA), at 60 min, but not 15, 30, or 180 min, after conditioning, and that this activation is attributable to pairedpresentations of tone and shock rather than to nonassociative auditory stimulation, foot shock sensitization, or unpaired tone-shock presentations. We next show that infusions of U0126, an inhibitor of ERK/MAPK activation, aimed at the LA, dose-dependently impair long-term memory of Pavlovian fear conditioning but leaves short-term memory intact. Finally, we show that bath application of U0126 impairs long-term potentiation in the LA in vitro. Collectively, these results demonstrate that ERK/MAPK activation is necessary for both memory consolidation of Pavlovian fear conditioning and synapticplasticity in the amygdala.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:27:01