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Titolo:
Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats
Autore:
Vrinten, DH; Gispen, WH; Groen, GJ; Adan, RAH;
Indirizzi:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Med Pharmacol, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Anesthesiol, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands NL-3584 CG Utrecht, Netherlands
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 20, anno: 2000,
pagine: 8131 - 8137
SICI:
0270-6474(20001101)20:21<8131:AOTMSR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC NEUROPATHIC PAIN; SUPERFICIAL DORSAL HORN; SCIATIC-NERVE INJURY; SPINAL-CORD; PERIPHERAL MONONEUROPATHY; OPIOID BINDING; MODEL; RECEPTORS; PEPTIDES; PROOPIOMELANOCORTIN;
Keywords:
neuropathic pain; chronic constriction injury; allodynia; melanocortins; melanocortin-4 receptor; spinal cord; dorsal horn; in situ I-125-NDP-MSH binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Adan, RAH Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Med Pharmacol, Univ Weg 100, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht Univ Weg 100 Utrecht Netherlands NL-3584 CG
Citazione:
D.H. Vrinten et al., "Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats", J NEUROSC, 20(21), 2000, pp. 8131-8137

Abstract

The presence of both pro-opiomelanocortin-derived peptides and melanocortin (MC) receptors in nociception-associated areas in the spinal cord suggests that, at the spinal level, the MC system might be involved in nociceptivetransmission. In the present study, we demonstrate that a chronic constriction injury (CCI) to the rat sciatic nerve, a lesion that produces neuropathic pain, results in changes in the spinal cord MC system, as shown by an increased binding of I-125-NDP-MSH to the dorsal horn. Furthermore, we investigated whether intrathecal administration (in the cisterna magna) of selective MC receptor ligands can affect the mechanical and cold allodynia associated with the CCI. Mechanical and cold allodynia were assessed by measuring withdrawal responses of the affected limb to von Frey filaments and withdrawal latencies upon immersion in a 4.5 degreesC water bath, respectively. We show that treatment with the MC receptor antagonist SHU9119 has a profound anti-allodynic effect, suggesting that the endogenous MC system has a tonic effect on nociception. In contrast, administration of the MC4 receptor agonists MTII and D-Tyr-MTII primarily increases the sensitivity to mechanical and cold stimulation. No antinociceptive action was observed after administration of the selective MC3 receptor agonist Nle-gamma -MSH. Together, our data suggest that the spinal cord MC system is involved in neuropathic pain and that the effects of MC receptor ligands on the responses to painful stimuli are exerted through the MC4 receptor. In conclusion, antagonism of the spinal melanocortin system might provide a new approach in the treatment of neuropathic pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:16:49