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Titolo:
Slow desensitization regulates the availability of synaptic GABA(A) receptors
Autore:
Overstreet, LS; Jones, MV; Westbrook, GL;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 20, anno: 2000,
pagine: 7914 - 7921
SICI:
0270-6474(20001101)20:21<7914:SDRTAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; CEREBELLAR GRANULE CELLS; RAT HIPPOCAMPAL-NEURONS; D-ASPARTATE RECEPTORS; OUTSIDE-OUT PATCHES; EXTRASYNAPTIC GLUTAMATE; POSTSYNAPTIC CURRENTS; UPTAKE INHIBITOR; NIPECOTIC ACID; CA1 NEURONS;
Keywords:
synaptic inhibition; desensitization; mIPSC; hippocampus; GABA transporters; ligand-gated ion channel; uptake blocker; postsynaptic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Overstreet, LS Oregon Hlth Sci Univ, Vollum Inst, L474,3181 SW Sam JacksonPk Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ L474,3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
L.S. Overstreet et al., "Slow desensitization regulates the availability of synaptic GABA(A) receptors", J NEUROSC, 20(21), 2000, pp. 7914-7921

Abstract

At central synapses, a large and fast spike of neurotransmitter efficiently activates postsynaptic receptors. However, low concentrations of transmitter can escape the cleft and activate presynaptic and postsynaptic receptors. We report here that low concentrations of GABA reduce IPSCs in hippocampal neurons by preferentially desensitizing rather than opening GABA(A) channels. GABA transporter blockade also caused desensitization by locally elevating GABA to similar to1 muM. Recovery of the IPSC required several seconds, mimicking recovery of the channel from slow desensitization. These results indicate that low levels of GABA can regulate the amplitude of IPSCs by producing a slow form of receptor desensitization. Accumulation of channelsin this absorbing state allows GABA(A) receptors to detect even a few molecules of GABA in the synaptic cleft.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:51:10