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Titolo:
Biglycan-like extracellular matrix genes of agnathans and teleosts
Autore:
Shintani, S; Sato, A; Toyosawa, S; OhUigin, C; Klein, J;
Indirizzi:
Max Planck Inst Biol, Immungenet Abt, D-72076 Tubingen, Germany Max PlanckInst Biol Tubingen Germany D-72076 D-72076 Tubingen, Germany
Titolo Testata:
JOURNAL OF MOLECULAR EVOLUTION
fascicolo: 4, volume: 51, anno: 2000,
pagine: 363 - 373
SICI:
0022-2844(200010)51:4<363:BEMGOA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRON-EXON JUNCTIONS; COMPLETE CDNA CLONING; LEUCINE-RICH REPEAT; CHROMOSOMAL LOCALIZATION; GENOMIC ORGANIZATION; ARTICULAR-CARTILAGE; KERATAN SULFATE; PROTEOGLYCAN-II; MESSENGER-RNA; CORE PROTEIN;
Keywords:
Petromyzon; Oreochromis; zebrafish; biglycan; decorin; proteoglycans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Klein, J Osaka Univ, Fac Dent, Dept Pedodont, 1-8 Yamadaoka, Suita, Osaka 5850871, Japan Osaka Univ 1-8 Yamadaoka Suita Osaka Japan 5850871 5850871, Japan
Citazione:
S. Shintani et al., "Biglycan-like extracellular matrix genes of agnathans and teleosts", J MOL EVOL, 51(4), 2000, pp. 363-373

Abstract

Biglycan and decorin are two members of a family of small extracellular matrix proteoglycans characterized by the presence of 10 leucine-rich repeatsand one or two attachment sites for glucosaminoglycans. Both have thus farbeen described only from tetrapod species, mainly mammals. Because the extracellular matrix has played an important part in the evolution of Metazoa,the phylogeny of its components is of considerable interest. In this study, biglycan-like (BGL) cDNA sequences have been obtained from two teleost (Oreochromis cichlid and zebrafish) and two lamprey species. The analysis of the sequences suggests that, like tetrapods, the lampreys possess two typesof proteoglycans, both of which are biglycan-like; decorin-like proteoglycans could not be identified in these species. The genes specifying these two types apparently arose by duplication in the lamprey lineage after its divergence from gnathostomes. The two teleost species possess a BGL proteoglycan and a bona fide decorin. The BGL proteoglycan is highly divergent from the tetrapod biglycan and related to the BGL proteoglycans of the lamprey. Hence, although the duplication generating the ancestors of biglycan and decorin genes occurred after the divergence of agnathans but before the emergence of teleosts, only decorin acquired its characteristic properties in the bony fishes. The BGL gene presumably turned into a typical biglycan only in the tetrapod lineages. The presumed acquisitions of new functions appearto have been accompanied by changes in the evolutionary rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:10:42