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Titolo:
Plasma interleukin-10 : tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications
Autore:
May, J; Lell, B; Luty, AJF; Meyer, CG; Kremsner, PG;
Indirizzi:
Humboldt Univ, Inst Trop Med Berlin, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 Med Berlin, D-14050 Berlin, Germany Humboldt Univ, Med Fak Charite, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 ak Charite, D-14050 Berlin, Germany Univ Tubingen, Inst Trop Med, Sekt Humanparasitol, Tubingen, Germany Univ Tubingen Tubingen Germany , Sekt Humanparasitol, Tubingen, Germany Bernhard Nocht Inst Trop Med, Sekt Trop Med Grundlagenforsch, Hamburg, Germany Bernhard Nocht Inst Trop Med Hamburg Germany enforsch, Hamburg, Germany Hop Albert Schweitzer, Lab Rech, Lambarene, Gabon Hop Albert Schweitzer Lambarene Gabon itzer, Lab Rech, Lambarene, Gabon
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 5, volume: 182, anno: 2000,
pagine: 1570 - 1573
SICI:
0022-1899(200011)182:5<1570:PI:TNF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM MALARIA; CEREBRAL MALARIA; ALPHA PROMOTER; POLYMORPHISM; REGION; ANEMIA; CHILDREN; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: May, J Humboldt Univ, Inst Trop Med Berlin, Spandauer Damm 130, D-14050 Berlin, Germany Humboldt Univ Spandauer Damm 130 Berlin Germany D-14050 n, Germany
Citazione:
J. May et al., "Plasma interleukin-10 : tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications", J INFEC DIS, 182(5), 2000, pp. 1570-1573

Abstract

In individuals with severe malarial anemia, plasma levels of tumor necrosis factor (TNF)-alpha tend to exceed those of interleukin (IL)-10, In this study, IL-10:TNF plasma level ratios <1 were found to be a risk factor for both cerebral malaria and severe anemia (P = .009), whereas higher IL-10:TNFratios were observed more frequently in hyperparasitemic individuals. Whenconsidering allelic variants of the TNF promoter in children with severe malaria, carriers of the wild type more frequently had an IL-10:TNF ratio >1(P = .008), In contrast, individuals with a mutation at position -238 of the TNF promoter (TNF-238A and TNF-376A/-238A) consistently had lower IL-10 than TNF plasma levels (IL-10:TNF ratio <1; P = .003), Our results show that, in children with severe malaria, TNF promoter variants influence the balance of IL-10:TNF in the plasma, which, in turn, affects the outcome in terms of clinical complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:12:34