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Titolo:
Emergence of CD8(+) T cells expressing NK cell receptors in influenza A virus-infected mice
Autore:
Kambayashi, T; Assarsson, E; Michaelsson, J; Berglund, P; Diehl, AP; Chambers, BJ; Ljunggren, HG;
Indirizzi:
Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Biol, S-17177 Stockholm, Sweden
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 165, anno: 2000,
pagine: 4964 - 4969
SICI:
0022-1767(20001101)165:9<4964:EOCTCE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; INHIBITORY RECEPTORS; LYMPHOKINE PRODUCTION; LYMPHOCYTES; MOUSE; MOLECULES; CRYSTALLIZATION; RECOGNITION; RESPONSES; SELF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ljunggren, HG Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Stockholm, Sweden
Citazione:
T. Kambayashi et al., "Emergence of CD8(+) T cells expressing NK cell receptors in influenza A virus-infected mice", J IMMUNOL, 165(9), 2000, pp. 4964-4969

Abstract

Both innate and adaptive immune responses play an important role in the recovery of the host from viral infections. In the present report, a subset of cells coexpressing CD8 and NKR-P1C (NK1.1) was found in the lungs of miceinfected with influenza A virus. These cells were detected at low numbers in the lungs of uninfected mice, but represented up to 10% of the total CD8(+) T cell population at day 10 postinfection, Almost all of the CD8(+)NK1.1(+) cells were CD8 alpha beta (+)CD3(+)TCR alpha beta (+) and a proportionof these cells also expressed the NK cell-associated Ly49 receptors, Interestingly, up to 30% of these cells were virus-specific T cells as determined by MHC class I tetramer staining and by intracellular staining of IFN-gamma after viral peptide stimulation. Moreover, these cells were distinct from conventional NKT cells as they were also found at increased numbers in influenza-infected CD1(-/-) mice. These results demonstrate that a significant proportion of CD8(+) T cells acquire NK1.1 and other NK cell-associated molecules, and suggests that these receptors may possibly regulate CD8(+) T cell effector functions during viral infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:26:43