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Titolo:
Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population that inhibits alloreactivity in vitro and in vivo
Autore:
Gorczynski, RM; Yu, K; Clark, D;
Indirizzi:
Univ Toronto, Hlth Network, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Hlth Network, Toronto, ON, Canada Univ Toronto, Dept Surg, Toronto, ON, Canada Univ Toronto Toronto ON Canada v Toronto, Dept Surg, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Immunol, Toronto, ON, Canada McMaster Univ, Dept Med Pathol, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada , Dept Med Pathol, Hamilton, ON, Canada McMaster Univ, Dept Mol Med Obstet & Gynecol, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada Obstet & Gynecol, Hamilton, ON, Canada
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 165, anno: 2000,
pagine: 4854 - 4860
SICI:
0022-1767(20001101)165:9<4854:REOCEA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL VENOUS IMMUNIZATION; RENAL-ALLOGRAFT SURVIVAL; DENDRITIC CELLS; IN-VIVO; SKIN-GRAFTS; RAT OX-2; B7-1; MURINE; PROLONGATION; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gorczynski, RM Toronto Hosp, CCRW 2-855,200 Elizabeth St, Toronto, ON M5G 2C4, Canada Toronto Hosp CCRW 2-855,200 Elizabeth St Toronto ON Canada M5G 2C4
Citazione:
R.M. Gorczynski et al., "Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population that inhibits alloreactivity in vitro and in vivo", J IMMUNOL, 165(9), 2000, pp. 4854-4860

Abstract

Increased survival of C57BL/6 renal allografts following portal vein donor-specific pretransplant immunization of C3H mice is associated with increased expression of the molecule OX2 seen on host dendritic cells, along with a marked polarization in cytokine production from lymphocytes harvested from the transplanted animals, with preferential production of IL-4, IL-10, and TGF-beta on donor-specific restimulation in vitro, and decreased production of IL-2, IFN-gamma, and TNF-alpha compared with non-portal vein-immunized control transplanted mice. The increased renal allograft survival and thealtered cytokine production are abolished by infusion of anti-mouse 052 mAb (3B6), Infusion of a soluble OX2:Fc immunoadhesin can itself produce significant prolongation of xeno- and allografts in mice. We have used FITC-conjugated OX2:Fc to characterize cells expressing a ligand (OX2L) for OX2, and provide evidence that subpopulations of LPS-stimulated splenic macrophages, Con A-activated splenic T cells, and the majority (>80%) of gamma delta TCR+ T cells express this ligand. We show below that F4/80(+), OX2L(+) splenic macrophages, admixed with OX2:Fc, represent a potent immunosuppressive population capable of causing more profound inhibition of alloreactivity invitro or in vivo than that seen using either OX2:Fc or OX2(+) (or OX2L(+))cells alone. Immunoregulation by this OX2L(+) population occurs in an MHC-restricted fashion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 22:43:12