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Titolo:
Post-cardiac transplantation gout: Incidence of therapeutic complications
Autore:
Wluka, AE; Ryan, PFJ; Miller, AM; Richardson, M; Bergin, PJ; Page, JL; Esmore, DS;
Indirizzi:
Alfred Hosp, Rheumatol Unit, Melbourne, Vic, Australia Alfred Hosp Melbourne Vic Australia atol Unit, Melbourne, Vic, Australia Alfred Hosp, Heart Lung Transplant Serv, Melbourne, Vic, Australia Alfred Hosp Melbourne Vic Australia lant Serv, Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 10, volume: 19, anno: 2000,
pagine: 951 - 956
SICI:
1053-2498(200010)19:10<951:PTGIOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPORTER STUDIED INVIVO; COLCHICINE SECRETION; URATE-OXIDASE; CYCLOSPORINE; RECIPIENTS; HEART; HYPERURICEMIA; AZATHIOPRINE; MYOPATHY; NEUROMYOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wluka, AE Alfred Hosp, Dept Med, Commercial Rd, Prahran, Vic 3181, Australia Alfred Hosp Commercial Rd Prahran Vic Australia 3181 , Australia
Citazione:
A.E. Wluka et al., "Post-cardiac transplantation gout: Incidence of therapeutic complications", J HEART LUN, 19(10), 2000, pp. 951-956

Abstract

Objective: To study the clinical impact of gout treatment following cardiac transplantation. Methods: We performed an audit of all cardiac transplant recipients of theAlfred Hospital before August 1998 who lived in Victoria. Results: We studied 225 patients (81% men), with a mean post-transplant follow-up of 50.8 months (SD 36), Forty-three (19%) had pre-transplant gout, 19 recurring posttransplantation. Twenty-three patients developed gout de novo. Of the 24 patients who received allopurinol, 6 developed pancytopenia and required hospitalization. Fourteen received a change in immunosuppression: in 5 patients following pancytopenia, and in 9 to enable safe use of allopurinol. Thirty-two patients received colchicine; 5 developed neuromyopathy. Impaired renal function, diuretic use, and hypertension were more common inthis sub-group. Non-steroidal antiinflammatory agents, used in 16 patients, caused serious complications in 1 patient (life-threatening peptic ulceration and hemorrhage, precipitating dialysis-dependent chronic renal failure). Conclusions: Cardiac transplant recipients, when treated for gout, are at high risk of therapeutic complications. Thus, gout treatment significantly affects care, health, and immunosuppression of these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:48:08