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Titolo:
Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia
Autore:
Panigrahy, A; Rosenberg, PA; Assmann, S; Foley, EC; Kinney, HC;
Indirizzi:
Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Neurol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA New England Res Inst, Watertown, MA 02472 USA New England Res Inst Watertown MA USA 02472 Inst, Watertown, MA 02472 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 427, anno: 2000,
pagine: 196 - 208
SICI:
0021-9967(20001113)427:2<196:DEOGRS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE-RECEPTOR; NUCLEUS-TRACTUS-SOLITARII; EXCITATORY AMINO-ACIDS; CENTRAL-NERVOUS-SYSTEM; GLYCINE BINDING-SITES; INFANT-DEATH-SYNDROME; DEVELOPING RAT-BRAIN; NMDA RECEPTOR; VENTILATORY RESPONSE; AMPA/KAINATE RECEPTORS;
Keywords:
AMPA receptor; excitotoxicity; kainate receptor; NMDA receptor; nucleus of the solitary tract;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Kinney, HC Childrens Hosp, Dept Pathol, Enders 206,300 Longwood Ave, Boston, MA 02115USA Childrens Hosp Enders 206,300 Longwood Ave Boston MA USA 02115
Citazione:
A. Panigrahy et al., "Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia", J COMP NEUR, 427(2), 2000, pp. 196-208

Abstract

This study delineates the development of N-methyl-D-aspartate (NMDA) and non-NMDA receptor binding in the human brainstem, particularly as it relatesto issues of the trophic effects of glutamate, the glutamate-mediated ventilatory response to hypoxia, and regional excitotoxic vulnerability to perinatal hypoxia-ischemia. We used tissue autoradiography to map the development of binding to NMDA, alpha -amino-3-hydroxy-5-methyl-4-isoxazole-proprionate (AMPA), and kainate receptors in brainstem sites involved in the glutamate ventilatory response to hypoxia, as well as recognized sites vulnerableto perinatal hypoxia-ischemia. NMDA receptor/channel binding was virtuallyundetectable in all regions of the human fetal brainstem at midgestation, an unexpected finding given the trophic role for NMDA receptors in early central nervous system maturation in experimental animals. In contrast, non-NMDA (AMPA and kainate) receptor binding was markedly elevated in multiple nuclei at midgestation. Although NMDA binding increased between midgestationand early infancy to moderately high adult levels, AMPA binding dramatically fell over the same time period to low adult levels. High levels of kainate binding did not change significantly between midgestation and infancy, except for an elevation in the infant compared with fetal inferior olive: after infancy, kainate binding decreased to negligible adult levels. Our datafurther suggest a differential development of components of the NMDA receptor/channel complex. This baseline information is critical in considering glutaminergic mechanisms in human brainstem development, physiology, and pathology. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 31/03/20 alle ore 10:26:45