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Titolo:
Tryptophan hydroxylase gene 218A/C polymorphism is not associated with depressed suicide
Autore:
Du, LS; Faludi, G; Palkovits, M; Bakish, D; Hrdina, PD;
Indirizzi:
Royal Ottawa Hosp, Mental Hlth Res Inst, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp Ottawa ON Canada K1Z 7K4 st, Ottawa, ON K1Z 7K4, Canada Univ Ottawa, Ottawa, ON K1Z 7K4, Canada Univ Ottawa Ottawa ON Canada K1Z 7K4 v Ottawa, Ottawa, ON K1Z 7K4, Canada Semmelweis Univ Med, H-1085 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1085 ed, H-1085 Budapest, Hungary
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 3, anno: 2000,
pagine: 215 - 220
SICI:
1461-1457(200009)3:3<215:THG2PI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; IMIPRAMINE BINDING-SITES; CEREBROSPINAL-FLUID; AFFECTIVE-DISORDERS; MONOAMINE METABOLITES; MAJOR DEPRESSION; 5-HT2 RECEPTORS; BEHAVIOR; VICTIMS; ALCOHOLISM;
Keywords:
tryptophan hydroxylase gene; depression; polymorphism; serotonin; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Du, LS Royal Ottawa Hosp, Mental Hlth Res Inst, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada Royal Ottawa Hosp 1145 Carling Ave Ottawa ON Canada K1Z 7K4 Canada
Citazione:
L.S. Du et al., "Tryptophan hydroxylase gene 218A/C polymorphism is not associated with depressed suicide", IN J NEUROP, 3(3), 2000, pp. 215-220

Abstract

Abnormalities in functioning of the central serotonergic system are believed to be involved in the pathogenesis of depressive illness and suicidal behaviour. Recently, polymorphism in the tryptophan hydroxylase (TPH) gene has been studied for association with aggression, anger-related traits and suicidal behaviour, but the results are inconclusive. The present investigation was to determine whether there are differences in genotype and allele distribution of the TPH gene 218A/C polymorphism in post-mortem brain samplesfrom 35 depressed suicide victims and 84 control subjects of the same ethnic background. A functional polymorphism in the promoter region of 5-HT transporter gene was also re-examined in this increased sample size. No significant difference in TPH gene 218A/C polymorphism between controls and depressed suicide victims was detected. This may suggest that the TPH gene has no significant effect on suicidality in depressed subjects. In a previous study on a smaller sample we found the frequency of the long allele of 5-HT transporter gene to be higher in depressed suicide victims. In this increased sample size, both the genotype and alleles of the 5-HT transporter gene were significantly associated with completed suicide. The frequency of the L/L genotype in depressed suicide victims was almost double of that found incontrol group (48.6 vs. 26.2%). The odds ratio for the L allele associatedwith depressed suicide was 2.1 (95% CI, 1.2-3.7). The relatively small sample size does not exclude the possibility of false-positive results and thefinding needs replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:56:22