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Titolo:
A PET study of [C-11]beta-CIT-FE binding to the dopamine transporter in the monkey and human brain
Autore:
Farde, L; Ginovart, N; Halldin, C; Chou, YH; Olsson, H; Swahn, CG;
Indirizzi:
Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 3, anno: 2000,
pagine: 203 - 214
SICI:
1461-1457(200009)3:3<203:APSO[B>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BETA-CIT-FE; LIVING HUMAN-BRAIN; MONOAMINE REUPTAKE SITES; C-11 RACLOPRIDE BINDING; D2-DOPAMINE RECEPTORS; PARKINSONS-DISEASE; UPTAKE INHIBITOR; PRIMATE BRAIN; COCAINE;
Keywords:
PET; dopamine transporter; human; monkey; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Farde, L Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 7176 Stockholm, Sweden
Citazione:
L. Farde et al., "A PET study of [C-11]beta-CIT-FE binding to the dopamine transporter in the monkey and human brain", IN J NEUROP, 3(3), 2000, pp. 203-214

Abstract

Several radiolabelled cocaine analogues have been proposed for brain imaging of the dopamine transporter in research on neuropsychiatric disorders and drug abuse. In a recent positron emission tomography (PET) study we labelled the cocaine analogue beta -CIT-FE with carbon-11 and demonstrated high specific binding in the monkey striatum. In the present study, the selectivity of [C-11]beta -CIT-FE binding in the primate brain was examined by pretreatment experiments with reference ligands for the dopamine, serotonin andnorepinephrine transporter. In three healthy human subjects the regional binding of [C-11]beta -CIT-FE was analysed using equilibrium and kinetic analyses. A Scatchard analysis showed that [C-11]beta -CIT-FE bound in a saturable manner yielded a density value of the same order as that reported in vitro. The pharmacological characterization indicated that a high degree of [C-11]-CIT-FE binding in the primate striatum represents the dopamine transporter. In human subjects the radioligand provided high brain up take and reached peak equilibrium within I hour after i.v, injection. Different quantitative approaches gave similar values for the binding potential. The results support the view that [C-11]beta -CIT-FE is a suitable radioligand for clinical studies of the dopamine transporter. In particular for studies requiring short data acquisition or repeated PET measurements on the same day.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:56:20