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Titolo:
Determination, diversification and multipotency of mammalian myogenic cells
Autore:
Cossu, G; De Angelis, L; Borello, U; Berarducci, B; Buffa, V; Sonnino, C; Coletta, M; Vivarelli, E; Bouche, M; Lattanzi, L; Tosoni, D; Di Donna, S; Berghella, L; Salvatori, G; Murphy, P; Cusella-de Angelis, MG; Molinaro, M;
Indirizzi:
Univ Rome La Sapienza, Dipartimento Istol & Embriol Med, Fdn Ist Pasteur Cenci Bolognetti, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 Bolognetti, I-00161 Rome, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
fascicolo: 6, volume: 44, anno: 2000,
pagine: 699 - 706
SICI:
0214-6282(2000)44:6<699:DDAMOM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING GROWTH-FACTOR; MOUSE PARAXIAL MESODERM; DORSAL NEURAL-TUBE; SONIC HEDGEHOG; SKELETAL-MUSCLE; CHICK LIMB; SPEMANN ORGANIZER; SATELLITE CELLS; FETAL MYOBLASTS; C2C12 MYOBLASTS;
Keywords:
myogenic determination; myogenic lineages; satellite cells; multipotent progenitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Cossu, G Univ Rome La Sapienza, Dipartimento Istol & Embriol Med, Fdn Ist Pasteur Cenci Bolognetti, Via A Scarpa 14, I-00161 Rome, Italy Univ Rome LaSapienza Via A Scarpa 14 Rome Italy I-00161 , Italy
Citazione:
G. Cossu et al., "Determination, diversification and multipotency of mammalian myogenic cells", INT J DEV B, 44(6), 2000, pp. 699-706

Abstract

In amniotes, myogenic commitment appears to be dependent upon signaling from neural tube and dorsal ectoderm, that can be replaced by members of the Wnt family and by Sonic hedgehog, Once committed, myoblasts undergo different fates, in that they can differentiate immediately to form the myotome, or later to give rise to primary and secondary muscle fibers. With fiber maturation, satellite cells are first detected; these cells contribute to fiber growth and regeneration during post-natal life. We will describe recent data, mainly from our laboratory, that suggest a different origin for some of the cells that are incorporated into the muscle fibers during late development. We propose the possibility that these myogenic cells are derived from the vasculature, are multi-potent and become committed to myogenesis by local signaling, when ingressing a differentiating muscle tissue. The implications for fetal and perinatal development of the whole mesoderm will also be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:38:52