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Titolo:
Intracellular mechanisms of antidepressant drug action
Autore:
Shelton, RC;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Psychiat, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 Psychiat, Nashville, TN 37240 USA Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 Pharmacol, Nashville, TN 37240 USA
Titolo Testata:
HARVARD REVIEW OF PSYCHIATRY
fascicolo: 4, volume: 8, anno: 2000,
pagine: 161 - 174
SICI:
1067-3229(200010)8:4<161:IMOADA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; RAT CEREBRAL-CORTEX; BETA-ADRENERGIC-RECEPTOR; PROTEIN-KINASE-A; AMP-GENERATING SYSTEM; MESSENGER-RNA LEVELS; PROLONGED GLUCOCORTICOID EXPOSURE; SEROTONIN REUPTAKE INHIBITOR; BIPOLAR DEPRESSED-PATIENTS; PITUITARY-ADRENAL AXIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Shelton, RC 1500 21st Ave S,Suite 2200, Nashville, TN 37212 USA 1500 21stAve S,Suite 2200 Nashville TN USA 37212 N 37212 USA
Citazione:
R.C. Shelton, "Intracellular mechanisms of antidepressant drug action", HARV R PSYC, 8(4), 2000, pp. 161-174

Abstract

The action of antidepressant drugs on monoamines such as norepinephrine and serotonin has been described for three decades. However, more-recent research has looked beyond cell surface receptors to transductional cascades and gene expression. Antidepressant drug therapies seem to share several mechanisms involved in either activating the adenylyl cyclase-protein kinase A cascade or inhibiting the phospholipase C-protein kinase C mechanisms. These effects, ultimately, combine to regulate the expression of target genes. Several specific genes are known to be activated or inhibited by antidepressant therapies. Steady-state levels of mRNA for glucocorticoid and mineralocorticoid receptors, brain-derived neurotrophic factor and its receptor trkB, and preproenkephalin are enhanced, whereas those for corticotropin-releasing hormone, c-fos, N-methyl-D-aspartate receptor subunits, and nerve-growth factor 1A are reduced. New molecular genetic methods for identifying differentially expressed genes will aid in the development of targets for wholly new generations of antidepressant drug therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:31:18