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Titolo:
5-HT3 and histamine H-1 receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats
Autore:
Jiang, W; Kreis, ME; Eastwood, C; Kirkup, AJ; Humphrey, PPA; Grundy, D;
Indirizzi:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England Univ Tubingen Hosp, Dept Gen Surg, Tubingen, Germany Univ Tubingen Hosp Tubingen Germany p, Dept Gen Surg, Tubingen, Germany Univ Cambridge, Glaxo Inst Appl Pharmacol, Cambridge, England Univ Cambridge Cambridge England nst Appl Pharmacol, Cambridge, England
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 5, volume: 119, anno: 2000,
pagine: 1267 - 1275
SICI:
0016-5085(200011)119:5<1267:5AHHRM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL COLITIS; MESENTERIC NERVES; ANTIGEN CHALLENGE; MAST-CELLS; VAGAL; JEJUNUM; FIBERS; COMMUNICATION; INVOLVEMENT; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Grundy, D Univ Sheffield, Dept Biomed Sci, Western Bank, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Western Bank Sheffield S Yorkshire England S10 2TN
Citazione:
W. Jiang et al., "5-HT3 and histamine H-1 receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats", GASTROENTY, 119(5), 2000, pp. 1267-1275

Abstract

Background & Aims: The mechanisms underlying brain stem activation during antigen challenge have not been resolved. Our aim was to characterize afferent nerve responses to intestinal anaphylaxis and determine the mediators involved in afferent activation. Methods: Mesenteric afferent discharge was recorded electrophysiologically after intestinal anaphylaxis in anesthetized rats previously sensitized to chicken egg albumin (EA), Results: Mesenteric afferent nerve discharge increased approximately 1 minute after luminal antigen but not bovine serum albumin (P < 0.001, EA vs. bovine serum albumin). Subsequent administration of antigen had no effect, but systemic EA evoked a marked increase in afferent discharge (P < 0.05), Afferent responses were unrelated to intestinal motor activity, and the response to luminal antigen was attenuated by luminal anesthetic (1% lidocaine), The 5-HT3-receptor antagonist alosetron (30 mug.kg(-1)) and the histamine H-1-receptor antagonist pyrilamine (5 mg kg(-1)) markedly attenuated the response to luminalantigen; pretreatment with doxantrazole attenuated responses to both luminal and systemic antigen. Conclusions: 5-HT3 and histamine, released from mast cells after intestinal anaphylaxis, stimulate mesenteric afferents via 5-HT3 and histamine H-1 receptors, Information on intestinal immune status is rapidly relayed to the central nervous system and may play a role in neural reflexes and behavioral responses following activation of the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:13:32