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Titolo:
Prognostic significance of p27, Ki-67, and topoisomerase II alpha expression in clinically nonfunctioning pancreatic endocrine tumors
Autore:
Chang, HJ; Batts, KP; Lloyd, RV; Sebo, TJ; Thompson, GB; Lohse, CM; Pankratz, SV;
Indirizzi:
Natl Med Ctr, Dept Pathol, Joong Ku, Seoul 100196, South Korea Natl Med Ctr Seoul South Korea 100196 oong Ku, Seoul 100196, South Korea Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Surg, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Biostat, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 stat, Rochester, MN 55905 USA
Titolo Testata:
ENDOCRINE PATHOLOGY
fascicolo: 3, volume: 11, anno: 2000,
pagine: 229 - 241
SICI:
1046-3976(200023)11:3<229:PSOPKA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; ISLET-CELL TUMORS; NEUROENDOCRINE TUMORS; P27(KIP1) EXPRESSION; SUPPRESSOR GENE; BREAST-CANCER; CARCINOMA; MARKER; PROLIFERATION; SURVIVAL;
Keywords:
nonfunctioning pancreatic endocrine tumor; prognosis; p27; Ki-67; topoisomerase II alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, HJ Natl Med Ctr, Dept Pathol, Joong Ku, 18-79 Ulchiro 6-Ka, Seoul 100196, South Korea Natl Med Ctr 18-79 Ulchiro 6-Ka Seoul South Korea 100196 Korea
Citazione:
H.J. Chang et al., "Prognostic significance of p27, Ki-67, and topoisomerase II alpha expression in clinically nonfunctioning pancreatic endocrine tumors", ENDOCR PATH, 11(3), 2000, pp. 229-241

Abstract

Nonfunctioning islet cell tumors or pancreatic endocrine tumors are the most common type of malignant islet cell tumor. Although previously detected usually at an advanced stage because of mass effect, the early detection rate of small localized disease has been increasing. To date it has been difficult to predict the clinical behavior in localized regional nonfunctioningtumors. To investigate potential markers predicting malignancy and poor prognosis in nonfunctioning pancreatic endocrine tumors, we a nalyzed the expression of Ki-67, topoisomerase II alpha (Topoll alpha), and p27, as well as a variety of clinicopathologic parameters in 76 cases of nonfunctioning islet cell tumors (23 benign cases and 53 malignant cases). Ki-67, Topoll alpha, and p27 labeling indices were significantly different between benign and malignant tumors. Expression of Ki-67, Topolla, and p27 were associated with survival in patients with a malignant tumor in a univariate setting. However, only p27 and Topoll alpha were jointly associated with survival in multivariate analysis. Immunohistochemical staining for p27, Topolla, and Ki-67 can be helpful in the diagnosis of nonfunctioning pancreatic endocrinetumor. Analysis of p27 and Topolla may also have potential utility as prognostic factors for malignant tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:10:09