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Titolo:
Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors - The insulin resistance and atherosclerosisstudy
Autore:
Bell, RA; Mayer-Davis, EJ; Martin, MA; DAgostino, RB; Haffner, SM;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Univ S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 l & Biostat, Columbia, SC 29208 USA Univ Texas, Div Clin Epidemiol, San Antonio, TX 78285 USA Univ Texas San Antonio TX USA 78285 Epidemiol, San Antonio, TX 78285 USA
Titolo Testata:
DIABETES CARE
fascicolo: 11, volume: 23, anno: 2000,
pagine: 1630 - 1636
SICI:
0149-5992(200011)23:11<1630:ABACAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BODY-WEIGHT; MYOCARDIAL-INFARCTION; CIGARETTE-SMOKING; DIABETES-MELLITUS; MEXICAN-AMERICANS; GLUCOSE-TOLERANCE; HEALTHY-SUBJECTS; SEX DIFFERENCE; JAPANESE MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Bell, RA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 7157 USA
Citazione:
R.A. Bell et al., "Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors - The insulin resistance and atherosclerosisstudy", DIABET CARE, 23(11), 2000, pp. 1630-1636

Abstract

OBJECTIVE - Light-to-moderate alcohol consumption has been associated withreduced cardiovascular disease (CVD) mortality, which may be explained by increased insulin sensitivity (S-I) and an improved Lipoprotein and blood pressure profile. Prior research has shown improved S-I with light-to-moderate alcohol intake even though somewhat imprecise measures of S-I were used. RESEARCH DESIGN AND METHODS - Relationships between alcohol use and S-I and CVD risk factors were assessed in a cross-sectional analysis of 1,196 white, African-American, and Hispanic men and women from the Insulin Resistance and Atherosclerosis Study (IRAS). Five categories of previous-year alcohol use (never, <0.5 drinks/day, 0.5-0.99 drinks/day, 1-2.99 drinks/day, and <greater than or equal to>3 drinks/day) and log S-I + 1 (frequently sampledintravenous glucose tolerance test with Bergman minimal model analysis), log fasting insulin, log triglycerides, HDL cholesterol, and systolic/diastolic blood pressure were examined using analysis of variance. RESULTS - Univariate analysis showed an inverse U-shaped relationship between S-I and alcohol intake, with a peak at the 0.5-0.99 drinks/day category. A W-shaped relationship was observed between fasting insulin and the lipid and blood pressure measures. After adjustment for demographic (clinic, sex, ethnicity, age), lifestyle (smoking, dietary energy/fat intake, physicalactivity), and physical (BMI, waist circumference) variables, the alcohol/insulin association was attenuated but the association with lipids and blood pressure remained for high-intake categories. CONCLUSIONS - These data suggest that the enhanced S-I associated with light-to-moderate alcohol consumption may be a function solely of a BMI and central adiposity profile more favorable to higher S-I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:56