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Titolo:
NGF expression in the developing rat brain: effects of maternal separation
Autore:
Cirulli, F; Alleva, E; Antonelli, A; Aloe, L;
Indirizzi:
Ist Super Sanita, Lab Fisiopatol Organ & Sistema, Sect Behav Pathophysiol,I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 hav Pathophysiol,I-00161 Rome, Italy Stanford Univ, Sch Med, Neurosci Program, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 rosci Program, Stanford, CA 94305 USA CNR, Inst Neurobiol, I-00156 Rome, Italy CNR Rome Italy I-00156CNR, Inst Neurobiol, I-00156 Rome, Italy
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 123, anno: 2000,
pagine: 129 - 134
SICI:
0165-3806(20001028)123:2<129:NEITDR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FACTOR MESSENGER-RNA; VISUAL-CORTEX; FACTOR GENE; INFANT RAT; DEPRIVATION; NEUROTROPHINS; RESPONSES; STRESS; HIPPOCAMPUS;
Keywords:
nerve growth factor; gene expression; development; maternal separation; central nervous system; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Cirulli, F Ist Super Sanita, Lab Fisiopatol Organ & Sistema, Sect Behav Pathophysiol,Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 aly
Citazione:
F. Cirulli et al., "NGF expression in the developing rat brain: effects of maternal separation", DEV BRAIN R, 123(2), 2000, pp. 129-134

Abstract

A number of studies have shown that mothering style in rodents can produceneuroendocrine, neurochemical and behavioural changes in the adult, although the basic mechanisms initiating this cascade of events still need to be investigated. Long term changes in neuronal function might be due to alterations in the expression of neurotrophins which have been shown to promote neuronal survival, differentiation and function during development, such as Nerve Growth Factor (NGF). NGF is essential for proper development of sympathetic and neural crest-derived sensory neurons of the peripheral nervous system as well as of central cholinergic neurons. In previous studies, usinga maternal separation paradigm, we have shown that NGF expression is increased in the dentate gyms and the hilus of the hippocampus as a result of brief (45 min) maternal separations. In the present study neonatal rats were separated for longer periods of time (up to 3 h) and at different ages during development (9 and 16 days postnatally). Results indicate that the effects of maternal separation on NGF expression are stronger with longer separations and are not restricted to the hippocampal region but can be seen alsoin other brain areas. Overall these results indicate that external factors, such as the presence/absence of the mother, can modify neurotrophic factor's availability in the brain, thus indicating NGF as a potential player inenvironmentally-mediated brain plasticity during development. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:05:11