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Titolo:
Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients
Autore:
Hartung, T; von Aulock, S; Freitag, M; Hoxtermann, S; Stucker, M; Hoffmann, K; Altmeyer, P; Kottke, A; Wendel, A;
Indirizzi:
Univ Konstanz, Dept Biochem Pharmacol, D-78457 Constance, Germany Univ Konstanz Constance Germany D-78457 acol, D-78457 Constance, Germany Ruhr Univ Bochum, Dept Dermatol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 Dermatol, D-4630 Bochum, Germany Essex Pharma GmbH, Munich, Germany Essex Pharma GmbH Munich GermanyEssex Pharma GmbH, Munich, Germany
Titolo Testata:
CYTOKINE
fascicolo: 10, volume: 12, anno: 2000,
pagine: 1570 - 1574
SICI:
1043-4666(200010)12:10<1570:BCROLM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; MICE;
Keywords:
blood; cytokines; growth factors; human; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Hartung, T Univ Konstanz, Dept Biochem Pharmacol, D-78457 Constance, Germany Univ Konstanz Constance Germany D-78457 57 Constance, Germany
Citazione:
T. Hartung et al., "Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients", CYTOKINE, 12(10), 2000, pp. 1570-1574

Abstract

We examined leukocyte counts and ex vivo cytokine response of whole blood to lipopolysaccharide (LPS) or lipoteichoic acid (LTA) in patients under low-dose molgramostim therapy. Patients were injected subcutaneously daily for ten days with 1 mug/kg (n=9) or 2 mug/kg (n=14) molgramostim, Leukocytosis was observed in all patients, but only the eosinophil fraction was significantly increased in relation to other leukocyte populations. Ex vivo IFN-gamma release was decreased and IL-10 and IL-1ra secretion were increased inresponse to LPS or LTA, Thus, in non-neutropenic patients, leukocytosis can already be initiated by low doses of molgramostim, The ex vivo cytokine data suggest that these doses prime blood towards a systemic anti-inflammatory response. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/07/18 alle ore 13:21:25