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Titolo:
S-adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats
Autore:
Deulofeu, R; Pares, A; Rubio, M; Gasso, M; Roman, J; Gimenez, A; Varela-Moreiras, G; Caballeria, J; Ballesta, AM; Mato, JM; Rodes, J;
Indirizzi:
Univ Barcelona, Hosp Clin & Prov, Alcohol Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ol Unit, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin & Prov, Biochem Lab, Barcelona, Spain Univ Barcelona Barcelona Spain in & Prov, Biochem Lab, Barcelona, Spain Univ Barcelona, Hosp Clin & Prov, Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 er Unit, E-08036 Barcelona, Spain Univ Navarra, Dept Med, Div Hepatol & Gene Therapy, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 ene Therapy, E-31080 Pamplona, Spain
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 4, volume: 99, anno: 2000,
pagine: 315 - 320
SICI:
0143-5221(200010)99:4<315:SPHTDI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSYL-L-METHIONINE; PERFORMANCE LIQUID-CHROMATOGRAPHY; ALCOHOLIC LIVER-CIRRHOSIS; ASCORBIC-ACID DEFICIENCY; LIPID-PEROXIDATION; VITAMIN-E; ALPHA-TOCOPHEROL; DOUBLE-BLIND; INTRAHEPATIC CHOLESTASIS; GLUTATHIONE;
Keywords:
ascorbic acid; CCl4; glutathione; lipid peroxidation; vitamin C; vitamin E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Pares, A Univ Barcelona, Hosp Clin & Prov, Alcohol Unit, C Villarroel 170,E-08036 Barcelona, Spain Univ Barcelona C Villarroel 170 Barcelona Spain E-08036 a, Spain
Citazione:
R. Deulofeu et al., "S-adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats", CLIN SCI, 99(4), 2000, pp. 315-320

Abstract

In various experimental models, S-adenosylmethionine (SAMe) has been shownto reduce liver injury by preventing depletion of glutathione, one of the antioxidant systems that plays a critical role in defence against oxidativestress. On the other hand, alpha -tocopherol may be decreased in liver diseases, and treatment with this vitamin reduces liver injury in CCl4-treatedrats. Since there is a close relationship among the different antioxidant systems (mainly glutathione, alpha -tocopherol and ascorbic acid), we have assessed whether, as well as restoring hepatic glutathione content, SAMe has any effect on liver alpha -tocopherol and ascorbic acid levels in CCl4-injured rats. Four groups of seven male Wistar rats treated for 9 weeks were stud led : rats induced to cirrhosis with CCl4, rats induced to cirrhosis plus SAMe administration (10 mg.kg(-1).day(-1)) and their respective controls. Liver samples were obtained for measuring levels of glutathione, alpha -tocopherol, ascorbic acid and thiobarbituric acid-reactive substances (TBARS), and hydroxyproline concentration as an index of collagen content. The hydroxyproline content was higher in CCl4-injured rats than in the control group (4.4+/-1.8 and 1.1+/-0.3 mu mol/g respectively; P < 0.05). In CCl4-injured rats, SAMe administration decreased collagen content (2.74 +/- 1.0 <mu>mol/g; P < 0.05) and TBARS, and corrected glutathione depletion. <alpha>-Tocopherol was significantly lower in CCl4-injured rats than in controls (17.3+/-4.9 and 23.0+/-4.0 mu mol/g respectively; P < 0.05). By contrast, <alpha>-tocopherol levels were similar (23.8+/-5.1 mu mol/g) in CCl4-injured rats receiving SAMe and in controls. In CCl4-injured rats, liver ascorbic acid was decreased in comparison with controls (4.9+/-1.8 and 8.2+/-1.0 mu mol/g respectively; P < 0.05), levels which were not replenished by SAMe (4.6+/-0.4 <mu>mol/g). In conclusion, SAMe not only decreases fibrosis and protects against hepatic glutathione depletion, but has a further antioxidant effect of preventing alpha -tocopherol depletion in CCl4-injured rats.

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Documento generato il 03/12/20 alle ore 14:12:07