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Titolo:
Serum leptin concentrations in patients with short-bowel syndrome
Autore:
Molina, A; Pita, A; Farriol, M; Virgili, N; Soler, J; Gomez, JM;
Indirizzi:
Ciutat Sanitaria I Univ Bellvitge, Dept Endocrinol & Nutr, Lhospitalet De Llobregat 08907, Barcelona, Spain Ciutat Sanitaria I Univ Bellvitge Lhospitalet De Llobregat Barcelona Spain 08907 Hosp Vall Hebron, CIBBIN, Barcelona, Spain Hosp Vall Hebron Barcelona Spain Vall Hebron, CIBBIN, Barcelona, Spain
Titolo Testata:
CLINICAL NUTRITION
fascicolo: 5, volume: 19, anno: 2000,
pagine: 333 - 338
SICI:
0261-5614(200010)19:5<333:SLCIPW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOME PARENTERAL-NUTRITION; BODY-COMPOSITION; HUMANS; KINETICS;
Keywords:
body composition; hyperphagia; leptin; short-bowel syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pita, A Ciutat Sanitaria I Univ Bellvitge, Dept Endocrinol & Nutr, Lhospitalet De Llobregat 08907, Barcelona, Spain Ciutat Sanitaria I Univ Bellvitge Lhospitalet De Llobregat Barcelona Spain 08907
Citazione:
A. Molina et al., "Serum leptin concentrations in patients with short-bowel syndrome", CLIN NUTR, 19(5), 2000, pp. 333-338

Abstract

Background: Short-bowel syndrome is a state of severe malabsorption resulting from absence or removal of the small bowel for several causes. A numberof short-bower patients develop hyperphagia. Leptin, a protein secreted from adipose tissue, signals the amount of energy stores to the brain. Objective: To study body composition and leptin regulation in short-bowel patients and to determine whether or not leptin concentrations are linked with hyperphagia. Design: We studied 25 short-bower patients (remnant bowel less than 150 cm) and 31 controls and 10 oral nutrition. Fifteen patients receivedtotal parenteral nutrition and 10 oral nutrition. Anthropometric measurements, body composition (by bioelectrical impedance), and cholesterol, triacylglycerol and leptin concentrations were studied in all subjects. Results: There were no differences between short-bowel patients and controls in anthropometric variables, body composition, or leptin concentrations. Leptin concentrations were higher in short-bovvel women than men (9.21 +/-8.54 vs. 3.22+/-1.86 ng/ml, P=0.01). Leptin concentrations correlated positively withage (r=0.4, P=0.045), body mass index (r=0.52, P=0.007), fat mass (r=0.67,P=0.001) and body fat (r=0.68, P=0.0001); there were no correlations with other body composition parameters. We found no correlations between parenteral or oral nutrition and body composition parameters, or between leptin concentrations and the presence of hyperphagia. Logistic regression analysis showed that body fat correctly identified leptin concentrations in 60% of patients. Conclusions: Body composition, leptin concentrations and leptin regulation in patients with short-bowel syndrome are similar to those of controls. Leptin concentrations do not correlate with hyperphagia in short bowel-patients. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:08:59