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Titolo:
Langerhans cell migration
Autore:
Cumberbatch, M; Dearman, RJ; Griffiths, CEM; Kimber, I;
Indirizzi:
Zeneca Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ e, England Univ Manchester, Hope Hosp, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD lford M6 8HD, Lancs, England
Titolo Testata:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
fascicolo: 5, volume: 25, anno: 2000,
pagine: 413 - 418
SICI:
0307-6938(200007)25:5<413:LCM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; IMMUNOSTIMULATORY DENDRITIC CELLS; CONTACT HYPERSENSITIVITY; INVITRO EVIDENCE; LYMPH-NODES; MICE; EXPRESSION; INTERLEUKIN-1-BETA; MATURATION; INDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cumberbatch, M Zeneca Cent Toxicol Lab, Alderley Pk, Macclesfield SK10 4TJ, Cheshire, England Zeneca Cent Toxicol Lab Alderley Pk Macclesfield Cheshire England SK10 4TJ
Citazione:
M. Cumberbatch et al., "Langerhans cell migration", CLIN EXP D, 25(5), 2000, pp. 413-418

Abstract

Epidermal Langerhans cells (LC) play pivotal roles in the induction of cutaneous immune responses. Encounter with antigen in the skin, or other stimuli, cause the mobilization of LC and their migration, via afferent lymphatics, to draining lymph nodes where they localize within the paracortex. During their movement from the skin LC acquire the characteristics of immunostimulatory dendritic cells (DC) such that the antigen-bearing cells which accumulate in lymph nodes are able to provoke specific T-lymphocyte responses. Epidermal cytokines initiate and regulate LC migration (and maturation), of particular importance being interleukin-1 beta and tumour necrosis factor-alpha. Collectively, these cytokines, together with relevant chemokine receptor-ligand interactions, effect the liberation of LC from the epidermis and their directed movement to, and localization within, peripheral lymph nodes. Described here are the phenotypic changes induced during the activation of LC and the mechanisms through which their migration is regulated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:36:55